| Qiuju Lin,Wenhui Li. The efficacy of 89Sr combined with 99Tc-MDP in the treatment of the advanced breast cancers with bone metastases. Oncol Transl Med, 2014, 13: 560-562. |
| The efficacy of 89Sr combined with 99Tc-MDP in the treatment of the advanced breast cancers with bone metastases |
| Received:November 24, 2014 Revised:December 09, 2014 |
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| KeyWord:breast cancer; bone metastases; 99Tc-MDP; 89Sr |
| Author Name | Affiliation | Postcode | | Qiuju Lin | The Second Division,Qingdao Cancer Hospital | 266042 | | Wenhui Li | The Second Division,Qingdao Cancer Hospital | |
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| Abstract: |
| Objective: The aim of our study was to evaluate the efficacy of 89Sr combined with Technetium [99Tc] Methylenediphosphonate Injection (99Tc-MDP) in the treatment of cancer pain in the advanced breast cancers with bone metastases. Methods: A total of 80 patients with various degrees of bone pain due to multiple metastases of breast cancer were treated with 89Sr combined with 99Tc-MDP. 89Sr was given intravenously at 4mCi on day 1 during the 3-month schedule. After 7 days, 99Tc-MDP was given at 22 mg/day on days 1–10 during the 1-month schedule, for 3 to 6 months. Results: The effective rate of relieving pain was 83.75%. The effective rate of curing bone metastases was 81.25%. So there was a significant improvement in the quality of life of the patients. Conclusion: 89Sr combined with 99Tc-MDP are effective in the treatment of cancer pain in the breast cancers with bone metastasis, and can obviously repair the bone destruction caused by metastases, thereby improving the quality of life in advanced breast cancer patients with bone metastases. |
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