| Qiuju Lin,Wenhui Li. The efficacy of 89Sr combined with 99Tc-MDP in the treatment of the advanced breast cancers with bone metastases. Oncol Transl Med, 2014, 13: 560-562. |
| 89锶联合云克治疗晚期乳腺癌骨转移80例疗效观察 |
| The efficacy of 89Sr combined with 99Tc-MDP in the treatment of the advanced breast cancers with bone metastases |
| Received:November 24, 2014 Revised:December 09, 2014 |
| DOI：10.1007/s10330-314-0029-1 |
| 中文关键词: 乳腺癌；骨转移；云克；89Sr |
| 英文关键词: breast cancer; bone metastases; 99Tc-MDP; 89Sr |
| 基金项目: |
| Author Name | Affiliation | Postcode | | Qiuju Lin* | The Second Division,Qingdao Cancer Hospital | 266042 | | Wenhui Li | The Second Division,Qingdao Cancer Hospital | |
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| 中文摘要: |
| 目的 观察89Sr 和云克联合治疗乳腺癌骨转移患者癌性疼痛的效果。方法 80例确诊为乳腺癌骨转移癌患者给予89Sr治疗，每次剂量：4mCi 静脉给药，间隔3 个月；7d后静脉滴注云克22mg/d，连续10d，每月一疗程，连用3~6 个月。结果 乳腺癌的止痛总有效率为83.75%。骨病灶消除有效率81.25% 。患者生存质量有明显改善。结论 89Sr和云克联合治疗乳腺癌骨转移引起的癌性疼痛，取得了很好的止痛效果，对转移癌引起的骨质破坏有明显的修复作用，从而在一定程度上提高晚期乳腺癌骨转移患者的生活质量。 |
| 英文摘要: |
| Objective: The aim of our study was to evaluate the efficacy of 89Sr combined with Technetium [99Tc] Methylenediphosphonate Injection (99Tc-MDP) in the treatment of cancer pain in the advanced breast cancers with bone metastases. Methods: A total of 80 patients with various degrees of bone pain due to multiple metastases of breast cancer were treated with 89Sr combined with 99Tc-MDP. 89Sr was given intravenously at 4mCi on day 1 during the 3-month schedule. After 7 days, 99Tc-MDP was given at 22 mg/day on days 1–10 during the 1-month schedule, for 3 to 6 months. Results: The effective rate of relieving pain was 83.75%. The effective rate of curing bone metastases was 81.25%. So there was a significant improvement in the quality of life of the patients. Conclusion: 89Sr combined with 99Tc-MDP are effective in the treatment of cancer pain in the breast cancers with bone metastasis, and can obviously repair the bone destruction caused by metastases, thereby improving the quality of life in advanced breast cancer patients with bone metastases. |
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