| Ping Yang,Jie Liu,Dongliang Lin,Haiyang Fu,Jing Chu,Feng Li,Guiyan Han,Yujun Li,Weiwei Fu. Clinical characteristics and prognostic analysis of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN). Oncol Transl Med, 2014, 13: 578-583. |
| Clinical characteristics and prognostic analysis of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) |
| Received:November 10, 2014 Revised:December 04, 2014 |
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| KeyWord:neuroendocrine neoplasm (NEN); pathology, prognosis; multiple factor analysis |
| Author Name | Affiliation | E-mail | | Ping Yang | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | 15865630@163.com | | Jie Liu | 2.Digestion Department of internal medicine hospital Economic and Technological Development Zone,Yantai 264000,China | | | Dongliang Lin | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | | | Haiyang Fu | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | | | Jing Chu | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | | | Feng Li | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | | | Guiyan Han | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | | | Yujun Li | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | liyujun.66@163.com | | Weiwei Fu | Department of Pathology, the Affiliated Hospital, Qingdao University, Qingdao 266003, China | |
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| Abstract: |
| Objective: The aim of the study was to analyze the clinicopathologic characteristics of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) and to explore the prognostic factors for patients and differences of immunohistochemical markers between neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC). Methods: Retrospective reviews were conducted for the charts of 119 patients with GEP-NEN at the Affiliated Hospital of Qingdao University (China) from August 2003 to December 2013. Kaplan-Meier method was used to do the overall survivals analysis for the patients at different levels of predictive factors. Meanwhile, Cox proportional hazard model was used to select independent risk factors of survival. Analysis of variance was used to compare the expression of immunohistochemical markers among different pathological grades. Results: Among 119 patients, pancreas (45/119, 37.82%) and rectum (33/119, 27.73%) were mostly involved. The onset age of GEP-NEN in female group was younger than that of the male group. There were 13 deaths (10.92%) during 18.9 (0.1–133.4) months follow-up period. Multivariate analysis indicated that neural invasion, gender and pathological grades of NET and NEC were independent risk factors. In neuroendocrine neoplasm (NEN), Syn expression in G2 was higher than G1 and G3, while CgA showed no significant difference. All markers showed no significant differences between NET and NEC. Conclusion: GEP-NEN may occur at multiple sites of digestive system and lack specific clinical manifestations. Syn expression detected for the prognosis of G1, G2 and G3 tumors have clinical significance. Neural invasion, sex and pathological grades were independent prognostic factors for GEP-NEN patients. No significant difference was found in different pathological grades of NET and NEC. |
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