| Wukui Huang,Dengyao Liu,Lina You,Shufa Yang,Mo Liu,Peng Gu,Pingju Wang,Baikere Pahaerding,Xiwen Fan. Jinlong capsule decreases adverse reactions after transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma. Oncol Transl Med, 2015, 1: 87-91. |
| 金龙胶囊减少肝癌患者TACE术后不良反应的临床分析 |
| Jinlong capsule decreases adverse reactions after transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma |
| Received:October 20, 2014 Revised:March 31, 2015 |
| DOI：10.1007/s10330-014-1416-y |
| 中文关键词: 金龙胶囊；肝癌；TACE；不良反应 |
| 英文关键词: Jinlong capsule; primary hepatocellular carcinoma (PHC); transcatheter arterial chemoembolization (TACE); adverse reaction |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Wukui Huang | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | huangwukui1982@sina.com | | Dengyao Liu | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | liudy1127@qq.com | | Lina You | Department of Traditional Chinese Medical, The Fifth Affilited Hospital of XinJiang Medical University, Urmqi, 830011, China. | | | Shufa Yang | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | | | Mo Liu | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | | | Peng Gu | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | | | Pingju Wang | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | | | Baikere Pahaerding | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | | | Xiwen Fan* | Department of Intervention Radiology, The Affilited Tumor Hospital of XinJiang Medical University, Urmqi, 830011, China | 1005978212@qq.com |
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| 中文摘要: |
| 目的 探讨金龙胶囊在减少原发性肝癌患者肝动脉插管灌注化疗栓塞术后不良反应方面的作用。方法 82例原发性肝癌患者按随机原则分为对照组和实验组。在肝动脉插管灌注化疗栓塞术后第1日，实验组患者开始口服金龙胶囊，对照组不服用，余治疗措施相同。结果 实验组患者血红细胞和血小板下降的例数较少（P<0.05）；两组总胆红素差异无统计学意义（P>0.05），谷丙转氨酶、血白蛋白、血钾、血钠与对照组比较差异有统计学意义（P<0.05）；实验组患者术后5日的食欲、精神、睡眠、疲乏评分情况优于对照组，腹痛、腹胀持续时间较短（P<0.05）。结论 金龙胶囊能减少TACE患者术后部分不良反应的发生，缩短不良反应持续的时间，能提高TACE患者术后近期生活质量，减少TACE对患者机体的损伤。 |
| 英文摘要: |
| Objective: The aim of this study was to analyze whether Jinlong capsule could decrease adverse reactions after transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma.
Methods: Eighty-two patients with hepatocellular carcinoma were randomly divided into the control group and experimental group. On the first day after TACE, the experimental group started receiving four Jinlong capsules orally three times daily, whereas the control group did not receive the treatment.
Results: The incidences of erythropenia and thrombocytopenia in the experimental group was lower than those in the control group (P = 0.040 and 0.033, respectively). The differences in serum levels of aminotransferase, albumin, otassium, and sodium between the two groups were significant (P = 0.034, 0.034, 0.013, and 0.044, respectively). The mean durations of stomachache and abdominal distension in the experimental group was significantly shorter than those in the control group (P = 0.004 and 0.021, respectively). However, there were no significant differences in the incidences of nausea, fever, and vomiting between the two groups (P = 0.490, 0.495, and 0.585, respectively).
Conclusion: The reduction in the incidence rate and duration of partial adverse reactions after TACE was observed in hepatocellular carcinoma patients treated with Jinlong capsule compared to untreated patients, suggesting possible beneficial effects exerted by Jinlong capsule on the reduction of TACE-induced liver damage, thereby improving liver function and, consequently, the quality of life. |
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