| ZhiWei Shao,Beibei Cong,Aihua Sui,Kai Meng,Yihe Dou. Expression of FOXG1 is associated with the malignancy of human glioma. Oncol Transl Med, 2014, 13: 594-599. |
| Expression of FOXG1 is associated with the malignancy of human glioma |
| Received:October 01, 2014 Revised:November 28, 2014 |
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| KeyWord:FOXG1; glioma; expression; apoptosis |
| Author Name | Affiliation | E-mail | | ZhiWei Shao | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qiingdao University, Qiingdao | 50202524@163.com | | Beibei Cong | Department of Immunological Laboratory, Qiingdao University School of Medicine, Qingdao University | | | Aihua Sui | Department of The Central Liboratology, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | | | Kai Meng | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | | | Yihe Dou | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | |
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| Abstract: |
| Objective: Recent evidence indicates that the increased expression of FOXG1 is associated with tumor genesis. This study was designed to explore the expression and role which FOXG1 plays in human glioma. Methods: We detected the expression of FOXG1 by immunohistochemistry in glioma tissue samples. Following the down-regulation of FOXG1 in
glioma cell lines by a specific short hairpin RNA, the function of FOXG1 in proliferation and apoptosis was assessed. Results: Glioma tissues exhibited notably higher expression of FOXG1 compared with control brain tissues and was positively correlated with histological malignancy. The down-regulation of FOXG1 in glioma cells led to a cell apoptosis in vitro. Conclusion: The overexpression of FOXG1 is a novel glioma malignancy marker, and FOXG1 may be used as a new target in therapeutic strategies for human glioma. |
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