| ZhiWei Shao,Beibei Cong,Aihua Sui,Kai Meng,Yihe Dou. Expression of FOXG1 is associated with the malignancy of human glioma. Oncol Transl Med, 2014, 13: 594-599. |
| FOXG1的表达与人类神经胶质瘤的恶性肿瘤有关 |
| Expression of FOXG1 is associated with the malignancy of human glioma |
| Received:October 01, 2014 Revised:November 28, 2014 |
| DOI：10.1007/s10330-314-0013-9 |
| 中文关键词: FOXG1; 胶质瘤; 表达; 凋亡 |
| 英文关键词: FOXG1; glioma; expression; apoptosis |
| 基金项目: |
| Author Name | Affiliation | E-mail | | ZhiWei Shao | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qiingdao University, Qiingdao | 50202524@163.com | | Beibei Cong | Department of Immunological Laboratory, Qiingdao University School of Medicine, Qingdao University | | | Aihua Sui | Department of The Central Liboratology, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | | | Kai Meng | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | | | Yihe Dou* | Department of Neurosurgery, the Affiliated Hospital of Qingdao University Medical College, Qingdao University | |
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| 中文摘要: |
| 目的:最近的证据表明,FOXG1表达的增加与肿瘤发生相关。本研究旨在探讨FOXG1在人类神经胶质瘤的表达和作用。方法:我们通过免疫组织化学方法检测FOXG1在神经胶质瘤组织样本的表达。接下来通过特定的短发卡RNA在神经胶质瘤细胞系下调FOXG1,FOXG1在增殖和凋亡的功能评估。结果:与对照组大脑组织相比，神经胶质瘤组织表现出明显高表达FOXG1。FOXG1与组织学恶性度呈正相关,。下调FOXG1的神经胶质瘤细胞在体外导致细胞凋亡。结论:FOXG1的过度表达是一种新型恶性胶质瘤的标记,FOXG1在人类神经胶质瘤的治疗策略可能作为新的靶点。 |
| 英文摘要: |
| Objective: Recent evidence indicates that the increased expression of FOXG1 is associated with tumor genesis. This study was designed to explore the expression and role which FOXG1 plays in human glioma. Methods: We detected the expression of FOXG1 by immunohistochemistry in glioma tissue samples. Following the down-regulation of FOXG1 in
glioma cell lines by a specific short hairpin RNA, the function of FOXG1 in proliferation and apoptosis was assessed. Results: Glioma tissues exhibited notably higher expression of FOXG1 compared with control brain tissues and was positively correlated with histological malignancy. The down-regulation of FOXG1 in glioma cells led to a cell apoptosis in vitro. Conclusion: The overexpression of FOXG1 is a novel glioma malignancy marker, and FOXG1 may be used as a new target in therapeutic strategies for human glioma. |
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