| Renmin Hospital,Chen Wei,Zhao Yu,Zhou Zhongyin,Luo Hesheng,Xu Ximing. The roles of microRNAs and epithelial-mesenchymal transition in colorectal cancer metastasis. Oncol Transl Med, 2014, 13: 545-548. |
| MicroRNA和EMT在结肠癌转移中的作用 |
| The roles of microRNAs and epithelial-mesenchymal transition in colorectal cancer metastasis |
| Received:September 27, 2014 Revised:November 02, 2014 |
| DOI：10.1007/s10330-314-0011-y |
| 中文关键词: 结直肠癌，microRNA，上皮间质转化，转移 |
| 英文关键词: colorectal cancer (CRC), microRNA, epithelial-mesenchymal transition (EMT), metastasis |
| 基金项目: |
| Author Name | Affiliation | Address | | Renmin Hospital | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | 武汉市解放路238号 | | Chen Wei | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Zhao Yu | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Zhou Zhongyin | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Luo Hesheng | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Xu Ximing* | Department of Oncology, Renmin Hospital, Wuhan University, Wuhan 430060, China | 湖北省武汉市解放路238号 |
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| 中文摘要: |
| 结直肠癌（CRC）是全球癌症相关死亡的第二大肿瘤，而远处转移则是结肠癌患者死亡的最主要原因。随着肿瘤的转移，肿瘤细胞从原发部位播散、种植到其他脏器，其间多种机制参与其中。肿瘤细胞增殖、侵入微环境并进入血液循环，最终到达并种植于远处脏器。MicroRNA和上皮间质转化（EMT）是肿瘤发生及转移的重要调控因子及机制。我们就结肠癌转移中microRNA和EMT，特别是EMT相关性microRNA的研究进展做一综述。MicroRNA将为结肠癌的治疗提供可能的分子靶标。 |
| 英文摘要: |
| Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. Distant metastasis is the major cause of death in patients with CRC. During progression to metastasis in which malignant cells disseminate from the primary tumor to seeding other organs, a multistep process is involved. Cancer cells proliferate, invade microenvironment, enter into the blood circulation, then survive and colonize into distant organs. MicroRNAs (miRNAs) and epithelial-mesenchymal transition (EMT) are key regulators and mechanism in tumorigenesis and cancer metastasis. We review the roles of EMT and microRNAs, especially EMT related microRNAs in the metastatic pathway of CRC. MicroRNAs provide us a set of potential therapeutic applications and molecular target for CRC. |
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