| 倪雅琼,Jiangqin Liu,Youxin Tian. Clinical value of cancer cells joint detection in peripheral blood plasma of thyroid cancer patients. Oncol Transl Med, 2014, 13: 518-522. |
| CK19与MUC1联合检测对诊断甲状腺癌循环血微转移的临床意义 |
| Clinical value of cancer cells joint detection in peripheral blood plasma of thyroid cancer patients |
| Received:September 24, 2014 Revised:November 07, 2014 |
| DOI：10.1007/s10330-314-0009-5 |
| 中文关键词: 甲状腺癌 流式细胞术 循环肿瘤细胞 细胞角蛋白 多态性上皮黏蛋白 |
| 英文关键词: thyroid cancer; flow cytometry; circulating tumor cells; cytokeratin; polymorphic epithelial mucin |
| 基金项目: |
| Author Name | Affiliation | Postcode | | 倪雅琼 | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | 730050 | | Jiangqin Liu* | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | 730050 | | Youxin Tian | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | |
|
| Hits: 11261 |
| Download times: 11347 |
| 中文摘要: |
| 目的 检测甲状腺癌外周血中细胞角蛋白19（CK19）和多态性上皮黏蛋白1(MUC1)表达，探讨其表达作为诊断循环血微转移的临床价值。方法 采用流式细胞术（FCM）对491例甲状腺癌外周血中CK19和MUC1表达细胞进行检测分析。结果 甲状腺癌外周血中CK19与MUC1表达与性别及年龄无统计学意义（P＞0.05）、与肿瘤大小、甲状腺包膜侵犯情况、淋巴结分期及远处转移的差异有显著性（P＜0.001），两项指标表达呈显著性正相关（r=0.628，P=0.000）。结论 甲状腺癌外周血中CK19与MUC1表达与肿瘤大小、侵犯程度及远处转移密切相关，外周血CK19与MUC1检测有助于预测甲状腺癌循环血微转移和预后评估。 |
| 英文摘要: |
| Objective: We aimed to detect cytokeratin 19 (CK19) and polymorphic epithelial mucin 1 (MUC1) expression in peripheral blood of thyroid cancer patients, and investigate the clinical value of it as a diagnostic marker for circulating blood micrometastases. Methods: The flow cytometry (FCM) was used to detect and analyze CK19 and MUC1-expressing cells in peripheral blood of 491 thyroid cancer patients. Results: CK19 and MUC1 expression showed no statistically significant difference with gender and age in thyroid cancer patients (P > 0.05), while had statistically significant difference with tumor size, lymph node stage and distant metastasis (P < 0.01). The expression of CK19 and MUC1 were positively correlated (r = 0.628, P = 0.00). Conclusion: CK19 is closely related to MUC1 expression, tumor size, extent of invasion and distant metastasis in peripheral blood of thyroid cancer patients. The circulating blood CK19 and MUC1 tests can help predict thyroid cancer micrometastases and prognosis. |
|
View Full Text
Download reader HTML全文 |
| Close |