| Guanzhong Zhang,Zhaozhe Liu,Tao Han,Fang Guo,Qingqing Sun,Yanan Ge,Yaling Han,Xiaodong Xie. Treatment of etoposide capsule combined with cisplatin or carboplatin in elderly patients with small cell lung cancer. Oncol Transl Med, 2014, 13: 528-531. |
| 依托泊苷胶囊联合顺铂或卡铂治疗老年小细胞肺癌的临床观察 |
| Treatment of etoposide capsule combined with cisplatin or carboplatin in elderly patients with small cell lung cancer |
| Received:September 11, 2014 Revised:November 03, 2014 |
| DOI：10.1007/s10330-314-0003-y |
| 中文关键词: 小细胞肺癌；依托泊苷胶囊；顺铂；卡铂；老年 |
| 英文关键词: small cell lung cancer (SCLC); etoposide capsule; cisplatin; carboplatin; elderly |
| 基金项目:the Sub-Topics of Major Drug Discovery Platform in the Twelfth-Five Year Research Program of China (No. 2012ZX09303016-002) and China Postdoctoral Science Foundation (No. 2012M512119). |
| Author Name | Affiliation | E-mail | | Guanzhong Zhang | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning, China 110016 | gzzhang2009@126.com | | Zhaozhe Liu | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning, China 110016 | lzz_summer@126.com | | Tao Han | Oncology Department,General Hospital of Shenyang Military Region,Shenyang,Liaoning | | | Fang Guo | Oncology Department,General Hospital of Shenyang Military Region,Shenyang,Liaoning | | | Qingqing Sun | Oncology Department,General Hospital of Shenyang Military Region,Shenyang,Liaoning | | | Yanan Ge | Oncology Department,General Hospital of Shenyang Military Region,Shenyang,Liaoning | | | Yaling Han | Cardiovascular disease institute,General Hospital of Shenyang Military Region,Shenyang,Liaoning | | | Xiaodong Xie* | Oncology Department,General Hospital of Shenyang Military Region,Shenyang,Liaoning | doctor_xxd@163.com |
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| 中文摘要: |
| 目的：研究依托泊苷胶囊联合顺铂或卡铂治疗老年小细胞肺癌病人的疗效及安全性。方法：回顾性分析2011年10月—2013年11月沈阳军区总医院经组织病理学证实的71-79岁的老年小细胞肺癌患者接受拉司太特胶囊150-175mg，d1-5；联合顺铂20mg/m2 d1-3或卡铂AUC=5，分2天应用，21天为1周期。结果：32例老年小细胞肺癌患者中完全缓解2例，部分缓解19例，稳定8例，进展3例，客观缓解率 65.6% (21/32)，疾病控制率90.6%(29/32)，中位无疾病进展时间为6.9月，中位生存时间为14.0月，1年生存率为62.4%。主要不良反应为Ⅰ/Ⅱ度白细胞减少和消化道反应。结论：依托泊苷胶囊联合顺铂或卡铂治疗老年小细胞肺癌患者疗效确切，耐受性好。 |
| 英文摘要: |
| Objective: We aimed to explore the efficacy and safety of etoposide capsule combined with cisplatin or carboplatin in the treatment of elderly patients with small cell lung cancer (SCLC). Methods: From October 2011 to November 2013, 32 elderly patients (71–79 years old) with histopathologically confirmed SCLC in General Hospital of Shenyang Military Region (China) were enrolled in the research. The patients were administrated with lastet capsule 150–175 mg, d1–5, combined with cisplatin 20 mg/m2 d1–3 or carboplatin AUC = 5, applied over 2 days. Twenty-one days were 1 treatment cycle. Results: After treatments, 2 cases acquired complete response (CR), 19 cases acquired partial response (PR), 8 cases acquired stable disease (SD), and 3 cases had progression of disease (PD). The objective response rate was 65.6% (21/32), disease control rate was 90.6% (29/32). The median time of progression-free survival (PFS) was 6.9 months, the median survival time was 14.0 months, and 1 year survival rate was 62.4%. The main adverse reactions of I/II leukopenia and astrointestinal reaction were observed. Conclusion: Etoposide capsule combined with cisplatin or carboplatin therapy have curative effect and good tolerance in elderly patients with SCLC. |
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