| Lei Kang,Xiaojie Xu,Hongwei Sun,Rongfu Wang. Role of F-18 FDG PET/CT imaging in the diagnosis of paraneoplastic neurological syndromes. Oncol Transl Med, 2014, 13: 494-498. |
| F-18 FDG PET/CT显像在诊断神经系统副肿瘤综合征的应用 |
| Role of F-18 FDG PET/CT imaging in the diagnosis of paraneoplastic neurological syndromes |
| Received:August 23, 2014 Revised:September 24, 2014 |
| DOI：10.1007/s10330-014-0050-z |
| 中文关键词: 神经系统副肿瘤综合征；脱氧氟代葡萄糖；PET/CT；抗神经元抗体 |
| 英文关键词: paraneoplastic neurological syndrome (PNS); FDG; PET/CT; anti-neuronal antibody |
| 基金项目:国家自然科学基金（81101065，31100604）、高等学校博士学科点新教师专项科研基金（20110001120043）、首都临床特色应用研究（Z141107002514159）、国家重大科学仪器设备开发专项（2011YQ03011409）基金 |
| Author Name | Affiliation | E-mail | | Lei Kang | Department of Nuclear Medicine,Peking University First Hospital | kanglei@bjmu.edu.cn | | Xiaojie Xu | Department of Medical Molecular Biology,Beijing Institute of Biotechnology | miraclexxj@126.com | | Hongwei Sun | Department of Nuclear Medicine,Peking University First Hospital | | | Rongfu Wang* | Department of Nuclear Medicine,Peking University First Hospital | rongfu_wang@163.com |
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| 中文摘要: |
| 神经系统副肿瘤综合征（paraneoplastic neurologic syndrome，PNS）是发生于某些恶性肿瘤患者体内神经系统表现异常的一类少见疾病，其临床表现多样，且神经系统症状的出现多早于恶性肿瘤的诊断。虽然抗神经元抗体对诊断PNS有提示作用，但是存在较多假阳性和假阴性情况。因此，PNS的诊断往往是临床工作的难点。PET/CT是一种解剖和功能的融合显像技术，通过一次扫描即可评价全身情况。脱氧氟代葡萄糖（FDG）PET/CT对于PNS的诊断优势不但在于能够显示全身范围内潜在的恶性肿瘤病灶，而且还可早期发现脑部代谢异常。此文通过介绍PNS的发病机制、临床表现、诊断程序以及FDG PET/CT在诊断PNS的研究进展作一综述，拟为临床上PNS的诊断提供帮助。 |
| 英文摘要: |
| Paraneoplastic neurological syndromes (PNS) is a series of rare neurologic disorders which happen with an underlying malignancy. It has various clinical symptoms proceding to the diagnosis of tumors. Although the abnormality of anti-neuronal antibodies is suggestive of PNS and tumors, there exist many false positive and false negative cases. The diagnosis of PNS is usually a challenge in clinic. Positron emission tomography/computed tomography (PET/CT) imaging is an anatomical and functional fusion imaging method, which provides the whole-body information by single scan. Fluorodeoxyglucose (FDG) PET/CT imaging can not only detect potential malignant lesions in the whole body, but also assess functional abnormality in the brain. In this review, the mechanism, clinical manifestation, diagnostic procedure and the recent progress of the utility of FDG PET/CT in PNS are introduced respectively. |
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