| Tenglong Zhang,Weili Jia,Li Sun,Xiaoyan Wang,Xiuhua Xing,Shuai Gong,Chunrui Yu. Expression and significance of microRNA-32 in multiple myeloma. Oncol Transl Med, 2014, 13: 472-475. |
| Expression and significance of microRNA-32 in multiple myeloma |
| Received:August 18, 2014 Revised:September 29, 2014 |
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| KeyWord:microRNA-32 (miR-32); multiple myeloma (MM); real-time polymerase chain reaction (real-time PCR) |
| Author Name | Affiliation | E-mail | | Tenglong Zhang | Department of Oncology, Qingdao Municipal Hospital | 331376656@qq.com | | Weili Jia | Department of Oncology, Qingdao Municipal Hospital | | | Li Sun | Department of Oncology, Qingdao Municipal Hospital | | | Xiaoyan Wang | Department of Oncology, Qingdao Municipal Hospital | | | Xiuhua Xing | Department of Oncology, Qingdao Municipal Hospital | | | Shuai Gong | Department of Oncology, Qingdao Municipal Hospital | | | Chunrui Yu | Department of Oncology, Qingdao Municipal Hospital | yuyouyoudangdang@sina.com |
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| Abstract: |
| Objective: This study was aimed to explore the expression of microRNA-32 (miR-32) in multiple myeloma (MM), and study its association with β2-microglobulin and staging of MM by Durie-Salmon classification. Methods: The expression level of miR-32 in bone marrow mono-nuclear cells of MM were examined by real-time polymerase chain reaction (real-time PCR), and the correlations between the expression level of miR-32 and related clinic pathologic features β2-microglobulin, staging of MM by Durie-Salmon classification were further analyzed. Results: The expression of miR-32 in MM patients was obviously higher than that in normal control (P < 0.05). The expression of miR-32 in relapsed/refractory MM patients was obviously higher than that in newly diagnosed MM patients. The expression of miR-32 in MM patients decreased after chemical therapy than that before treatment, especially in effective group (P < 0.05). There was no statistically significant change in ineffective/progress group after chemical therapy (P > 0.05) .The expression of miR-32 was associated to staging of MM and β2-microglobulin level. Conclusion: Expression level of miR-32 in MM patients is significantly higher than that in normal bone marrow, these data indicated that miR-32 may play an important role in the development of MM. High-regulated expression of miR-32 was associated with β2-microglobulin and staging of MM by Durie-Salmon classification. |
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