| Shuxian Qu,Zhendong Zheng,Zhaozhe Liu,Liang Liu,Miao Zhang,Yaling Han,Xiaodong Xie. Correlation between the expression of vascular endothelial growth factor c and C-erbB-2 in human breast cancer. Oncol Transl Med, 2014, 13: 464-467. |
| 血管内皮生长因子C与人类表皮生长因子-2在人类乳腺癌中表达的相关性研究 |
| Correlation between the expression of vascular endothelial growth factor c and C-erbB-2 in human breast cancer |
| Received:August 15, 2014 Revised:September 26, 2014 |
| DOI：10.1007/s10330-014-0045-9 |
| 中文关键词: 乳腺癌；血管内皮生长因子-C；人表皮生长因子-2 |
| 英文关键词: breast cancer; vascular endothelial growth factor C; C-erbB-2 |
| 基金项目:1. 国家十二五重大新药创制平台子课题（2012ZX09303016-002） 2. 2012年辽宁省科技攻关计划课题（2012225019） |
| Author Name | Affiliation | E-mail | | Shuxian Qu | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, China | qushuxian2010@163.com | | Zhendong Zheng | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Zhaozhe Liu | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Liang Liu | Oncology Department, The Thhird Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, 550001, China | | | Miao Zhang | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Yaling Han | Cardiology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Xiaodong Xie* | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | doctor_xxd@163.com |
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| 中文摘要: |
| 目的：探讨血管内皮生长因子C（VEGF-C）在人类乳腺组织中的转录水平，并分析其与C-erbB-2表达水平的相关性。方法：应用原位杂交方法检测51例人乳腺癌组织标本中VEGF-C mRNA表达，应用免疫组化方法检测C-erbB-2表达。结果：51例组织标本中VEGF-C mRNA的阳性表达率为54.9%，且其转录水平和肿瘤大小及淋巴结转移数目相关（(P<0.050.同时和C-erbB-2的表达水平相关 (P<0.05)。结论：VEGF-C表达的增加与乳腺癌的恶性度和临床分期显著相关，VEGF-C, C-erbB-2的联合检测可能更好的预测乳腺癌的预后，并且有望更精确的指导靶向药物开发和应用。 |
| 英文摘要: |
| Objective: We aimed to study the transcription level of VEGF-C in human breast cancer tissue, and explore the correlations with the expression of C-erbB-2. Methods: The expression of VEGF-C mRNA in 51 cases of human breast cancer was assessed by hybridization in situ. The expressions of C-erbB-2 was assessed by immunohistochemistry. Results: The positive rate of VEGF-C mRNA was 54.9% in 51 cases of breast cancer. The transcription level had correlation with tumor size and status of lymph nodes (P < 0.05). The expression of VEGF-C mRNA had a positive correlation with the expression of C-erbB-2 (P < 0.05). Conclusion: The up-expression of VEGF-C has a significant correlation with the malignancy level and clinical stage of breast cancer. The combined detection of VEGF-C, C-erbB-2 may help to estimate the prognosis of patients with breast cancer and study on thetherapeutic implications. |
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