| Minghui Zhang,Decai Chi,Shu Zhao,Yan Wang,Maopeng Yang,Yan Wang. Circulating tumor cells in lung cancer: Detection methods and clinical impact. Oncol Transl Med, 2014, 13: 476-482. |
| 循环肿瘤细胞的检测方法及其在肺癌临床中的应用 |
| Circulating tumor cells in lung cancer: Detection methods and clinical impact |
| Received:August 01, 2014 Revised:September 25, 2014 |
| DOI：10.1007/s10330-014-0041-0 |
| 中文关键词: 循环肿瘤细胞；肺癌；富集方法；检测方法 |
| 英文关键词: circulating tumor cells (CTCs); lung cancer; enrichment method; detection method |
| 基金项目:黑龙江省自然科学基因（H201335），卫生部科技发展中心基金（W2012FZ105） |
| Author Name | Affiliation | E-mail | | Minghui Zhang | Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China | zhmhui1985@163.com | | Decai Chi | Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China | 279301085@qq.com | | Shu Zhao | Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China | | | Yan Wang | Department of Medical Oncology, Heilongjiang Provincial Hospital, Harbin 150081, China | | | Maopeng Yang | Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China | | | Yan Wang* | Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China | wangyan86298263@163.com |
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| 中文摘要: |
| 肺癌主要的死亡原因为转移灶的形成。循环肿瘤细胞（CTCs）是由肿瘤细胞由原发部位脱落，进入血液循环形成，CTCs到达远处器官形成转移灶。外周血中CTC的存在与肺癌的疾病进展密切相关，但由于外周血中肿瘤细胞数量少，富集及检测技术为目前主要的面临的挑战。为了进一步更好的了解CTCS研究进展，本综述主要探讨CTCs的不同检测方法及CTCs在肺癌中的意义和作为生物标志物指导预后的价值。 |
| 英文摘要: |
| Circulating tumor cells (CTCs) are tumor cells that enter the blood circulation after detaching from the primary tumor and can migrate to reach distant organs, where they can give rise to aggressive metastasis. Clinical studies have revealed that the presence of CTCs in peripheral blood is correlated with disease progression in lung cancer. However, as CTCs are rare cancer cells released from tumors into the bloodstream, both enrichment and sensitive detection methods are technically challenging. In order to best understand how CTCs are currently being deployed, this review mainly focuses on the different detection methods for CTCs. Furthermore, we will describe the clinical impact of circulating tumor cells in lung cancer and discuss their potential use as biomarker to guide the prognosis. |
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