Minghui Zhang,Decai Chi,Shu Zhao,Yan Wang,Maopeng Yang,Yan Wang. Circulating tumor cells in lung cancer: Detection methods and clinical impact. Oncol Transl Med, 2014, 13: 476-482.
Circulating tumor cells in lung cancer: Detection methods and clinical impact
Received:August 01, 2014  Revised:September 25, 2014
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KeyWord:circulating tumor cells (CTCs); lung cancer; enrichment method; detection method
Author NameAffiliationE-mail
Minghui Zhang Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China zhmhui1985@163.com 
Decai Chi Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China 279301085@qq.com 
Shu Zhao Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China  
Yan Wang Department of Medical Oncology, Heilongjiang Provincial Hospital, Harbin 150081, China  
Maopeng Yang Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China  
Yan Wang Department of Medical Oncology, The Tumor Hospital of Harbin Medical University, Harbin 150081, China wangyan86298263@163.com 
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Abstract:
      Circulating tumor cells (CTCs) are tumor cells that enter the blood circulation after detaching from the primary tumor and can migrate to reach distant organs, where they can give rise to aggressive metastasis. Clinical studies have revealed that the presence of CTCs in peripheral blood is correlated with disease progression in lung cancer. However, as CTCs are rare cancer cells released from tumors into the bloodstream, both enrichment and sensitive detection methods are technically challenging. In order to best understand how CTCs are currently being deployed, this review mainly focuses on the different detection methods for CTCs. Furthermore, we will describe the clinical impact of circulating tumor cells in lung cancer and discuss their potential use as biomarker to guide the prognosis.
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