| Shihong Ma,Jiangqin Liu,Xiaofeng Hou. Correlation between thyroid function and nodular goiter accompanied with gallstone. Oncol Transl Med, 2014, 13: 360-362. |
| 结节性甲状腺肿伴发胆囊结石与甲状腺功能的相关性 |
| Correlation between thyroid function and nodular goiter accompanied with gallstone |
| Received:July 30, 2014 Revised:July 30, 2014 |
| DOI：10.1007/s10330-014-1345-9 |
| 中文关键词: 结节性甲状腺肿; 胆囊结石; 甲状腺功能 |
| 英文关键词: nodular goiter; gallstone; thyroid function |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Shihong Ma | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | LIUQJ99@126.com | | Jiangqin Liu* | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | LIUQJ99@126.com | | Xiaofeng Hou | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | |
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| 中文摘要: |
| 目的: 研究甲状腺功能与结节性甲状腺肿伴发胆囊结石的关系。方法: 收集结节性甲状腺肿伴发胆囊结石患者120例、结节性甲状腺肿128例并设健康对照组50例，采用电化学发光法检测外周静脉血促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT3)和总甲状腺素(TT4)水平，酶法测定血清总胆固醇（TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和血清总胆汁酸(TBA)水平，观察三组之间甲状腺功能和血脂变化。结果: 结节性甲状腺肿伴发胆囊结石组、结节性甲状腺肿组TT3水平均显著低于对照组(P＜0．01)，结节性甲状腺肿伴发胆囊结石组TSH水平显著高于对照组(P＜0．01) 。三组TT4水平差异无统计学意义(P＞0．05)。结节性甲状腺肿伴发胆囊结石组TC和LDL-C显著高于结节性甲状腺肿组和对照组(P＜0．01)，而结节性甲状腺肿伴发胆囊结石组TBA低于单纯结节性甲状腺肿组和对照组(P＜0．01)。单纯结节性甲状腺肿组和对照组TC和LDL-C水平差异均无统计学意义(P＞0．05) ，而伴发胆囊结石组和对照组HDL-C 水平均明显高于单纯甲状腺肿组(P＜0．01)。结论: 结节性甲状腺肿伴发胆囊结石的发病始动因素可能与TT3降低导致亚临床甲状腺功能减退有关。 |
| 英文摘要: |
| Objective: The purpose of the study is to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods: We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone (TSH), total triiodothyronine (TT3), total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemiluminescence immunoassay, measure level of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total bile acid (TBA) levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results: The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group (P < 0.01), and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group (P < 0.01). There were no statistical significance about difference of TT4 level among the three groups (P > 0.05). Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group (P < 0.01), while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group (P < 0.01). There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group (P > 0.05). The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group (P < 0.01). Conclusion: The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism. |
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