| Yingying Sun,Huaqing Lin. Research rogress in Nanoparticles as Anticancer Drug Carrier. Oncol Transl Med, 2014, 13: 489-493. |
| 纳米粒作为抗肿瘤药物载体的研究进展 |
| Research rogress in Nanoparticles as Anticancer Drug Carrier |
| Received:July 28, 2014 Revised:September 01, 2014 |
| DOI：10.1007/s10330-014-0039-7 |
| 中文关键词: 纳米粒;抗肿瘤药物 药物载体 |
| 英文关键词: Nanoparticles; anticancer drugs; drug carrier |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Yingying Sun | Department of Guangdong Pharmacy College, Guangdong Key Laboratory for New Pharmaceutical Dosage Forms, Guangzhou 510006, China | 18814099672@163.com | | Huaqing Lin* | Department of Guangdong Pharmacy College, Guangdong Key Laboratory for New Pharmaceutical Dosage Forms, Guangzhou 510006, China | huaqing_@vip.tom.com |
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| 中文摘要: |
| 纳米粒载药系统可以改变药物的体内分布特征,具有缓控释和靶向给药特性,增加药物的稳定性,提高药物的生物利用度。纳米粒的选择性靶向可以通过增强渗透滞留效应(EPR)、偶联特定的配体,或由于生理条件如pH值、温度等的改变实现。纳米粒可以由多种材料制备并且用于包合各种化学治疗药物以降低毒副作用,其中,磁性纳米粒作为抗肿瘤药物载体不仅可以用来治疗还能用于成像诊断。本文综述了纳米粒被动靶向、主动靶向、物理化学靶向给药系统用于抗肿瘤药物载体的进展。 |
| 英文摘要: |
| Nanoparticles drug carrier system has sustained and controlled release features as well as targeted drug delivery, which can change the characteristics of drug distribution in vivo. It can increase the stability of the drug and enhance drug bioavailability. The selective targeting of nanoparticles can be achieved through enhanced permeability and retention effect and a conjugated specific ligand or through the effects of physiological conditions, such as pH and temperature. Nanoparticles can be prepared by using a wide range of materials and can be used to encapsulate chemotherapeutic agents to reduce toxicity with the magnetic nanoparticles as the anticancer drug carrier, which can be used for imaging, therapy, and diagnosis. In this study, In this study, Recent progress on nanoparticles as a targeted drug delivery system will be reviewed, including positive-targeting, negative-targeting, and physicochemical-targeting used as anticancer drug carrier. |
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