| juping Rui,Guochang Chen,Boneng Mao,Qi Pan. The vacA i1 genotype of Helicobacter pylori is associated with peptic ulcer and gastric cancer: A meta-analysis. Oncol Transl Med, 2014, 13: 401-409. |
| 幽门螺杆菌VacA i1基因型与消化性溃疡及胃癌发生相关：荟萃分析 |
| The vacA i1 genotype of Helicobacter pylori is associated with peptic ulcer and gastric cancer: A meta-analysis |
| Received:July 04, 2014 Revised:August 26, 2014 |
| DOI：10.1007/s10330-014-0029-9 |
| 中文关键词: vcaA基因；中间区域；幽门螺杆菌相关疾病 |
| 英文关键词: vacA gene; intermediate region; H. pylori-associated diseases |
| 基金项目:国家自然科学基金（No.81072032,30770992） |
| Author Name | Affiliation | E-mail | | juping Rui* | Department of Gastroenterology, Yixing Hospital, Jiangsu University, Yixing 214200, China | staff1178@yxph.com | | Guochang Chen | Yixing Hospital, Jiangsu University, Yixing 214200, China | | | Boneng Mao | Department of Gastroenterology, Yixing Hospital, Jiangsu University, Yixing 214200, China | | | Qi Pan | Department of Gastroenterology, Yixing Hospital, Jiangsu University, Yixing 214200, China | |
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| 中文摘要: |
| 背景与目的：VacA中间基因型存在两个区域，i1和i2，然而，该基因型与胃十二指肠疾病之间的关联尚待阐明。本文的目的是探讨该基因型与幽门螺旋杆菌相关的疾病，例如慢性胃炎，消化性溃疡病与胃癌之间的相互作用。方法：本项荟
萃分析使用的制作软件是Review Manager 4.2.2。结果：11篇（十篇文章和一篇摘要）符合纳入标准的文章被纳入研究。i1基因型增加了消化性溃疡(比值比=1.70, 95%可信区间:1.24-2.33, P<0.001)和胃癌 (比值比=3.90, 95%可信区间: 2.64-5.78, P<0.001）的患病风险。子分析提示i1基因型与胃溃疡(比值比=2.59, 95%可信区间: 1.05-6.35, P=0.040)显著相关，而与十二指肠球部溃疡(比值比=1.04, 95%可信区间: 0.61-1.76, P=0.90)关系不大。此外，i1基因型与消化性溃疡及胃癌关系的研究不仅来自亚洲，而且在欧洲也存在，除了亚洲人口i1基因型与消化性溃疡无关。结论：VacA i1基因型可以增加消化性溃疡（主要为胃溃疡）及胃癌的发生风险。地理分布上，除了亚洲人口i1基因型与消化性溃疡无关外，i1基因型与消化性溃疡及胃癌关系的研究不仅来自欧洲，而且也存在于亚洲。 |
| 英文摘要: |
| Objective: There are two genotypes of the vacA intermediate region, i1 and i2; however, the association between the genotypes and gastroduodenal disease remains to be elucidated. The aim of this article was to investigate the interaction between the genotypes and H. pylori-associated diseases such as chronic gastritis, peptic ulcer disease (PUD) and gastric cancer. Methods: The meta-analysis was performed in Review Manager 4.2.2. Results: Eleven (ten articles and one abstract) met the inclusion criteria and were included. The i1 genotype increased the risk of PUD (OR = 1.70, 95% CI: 1.24–2.33, P < 0.001) and gastric cancer (OR = 3.90, 95% CI: 2.64–5.78, P < 0.001). Sub-analysis showed that the i1 genotype was signifi-cantly associated with gastric ulcers (OR = 2.59, 95% CI: 1.05–6.35, P = 0.040), but not with duodenal ulcers (OR = 1.04, 95% CI: 0.61–1.76, P = 0.90). In addition, the association between the i1 genotype and PUD and GC existed in studies not only from Europe but also Asia, except for the association between the i1 genotype and PUD in Asian population. Conclusion: The vacA i1 genotype is associated with an increased risk of the development of peptic ulcer disease (mainly gastric ulcer) and gastric cancer. In geographical distribution, the association between the i1 genotype and PUD and GC existed in studies not only from Europe but also Asia, except for the association between the i1 genotype and PUD in Asian population. |
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