| Sen Xie,Ligong Tang,Xiong Cai,Zhixiong Li,Huanhuan Chen,Hui Bao. Might liver transplantation recipients with primary hepatocellular carcinoma benefit from GVT effect of aGVHD?. Oncol Transl Med, 2014, 13: 535-538. |
| 肝癌肝移植受者急性移植物抗宿主病存在移植物抗肿瘤效应吗？ |
| Might liver transplantation recipients with primary hepatocellular carcinoma benefit from GVT effect of aGVHD? |
| Received:June 30, 2014 Revised:November 03, 2014 |
| DOI：10.1007/s10330-014-0013-4 |
| 中文关键词: 肝癌 肝移植 急性移植物抗宿主病 移植物抗肿瘤效应 |
| 英文关键词: hepatocellular carcinoma (HCC); liver transplantation; acute graft versus host disease; graft versus tumor |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Sen Xie* | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | dr.xiesen@medmail.com.cn | | Ligong Tang | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | | | Xiong Cai | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | | | Zhixiong Li | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | | | Huanhuan Chen | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | | | Hui Bao | Department of Organ Transplantation,Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China | |
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| 中文摘要: |
| 目的 探讨肝癌(hepatocellular carcimoma，HCC)肝移植受者急性移植物抗宿主病（acute graft versus host disease，aGVHD）除造成免疫损伤外，是否也可能存在移植物抗肿瘤效应（Graft versus tumor，GVT），有利于防治肿瘤复发。方法 动态观察3例进展期肝癌合并肝硬化患者，在肝移植术后出现高热、皮疹及水样便，最终诊断aGVHD。患者经甲基强的松龙冲击，停止口服免疫抑制剂，补充大剂量人免疫球蛋白及抗感染，2例治愈。规则随访幸存者肝癌复发的生物学和影像学指标。结果 2例患者随访迄今96月和17月，血常规和血清AFP检测一直正常，移植肝功能稳定。影像学检查无移植肝、肺部、颅内及其他组织器官肿瘤复发转移征象。结论 肝癌肝移植受者并发aGVHD，除可造成显著的组织器官损伤致死外，推测它也同时存在GVT效应，有利于防治肿瘤复发，results in幸存者可获得长期健康存活。 |
| 英文摘要: |
| Objective: We aimed to access if acute graft-versus-host disease (aGVHD) in liver transplantation recipients of hepatocellular carcinoma (HCC) might develop a graft-versus-tumor effect (GVT) other than immunological damage which would benefit prophylaxis of tumor recurrence. Methods: Dynamic observation of 3 cases of liver transplantation recipients of HCC and cirrhosis, which developed manifestations of fever, skin rash, watery diarrhea, pancytopenia and were finally diagnosed as aGVHD. Two of which got recovered from intravenously pulse methylprednisolone, high-dose intravenous immunoglobulin, antibiotics administration simultaneously and promptly withdrawal of oral immunosuppressants. Two survivors were follow-up regularly with biological monitoring and imaging surveillance for tumor recurrence thereafter. Results: Two recipients survived healthily with stable liver graft function and normal serum AFP level and blood routine test. No sign of tumor recurrence was found in repeat imaging examinations for liver graft, lung, brain and other tissue or organs within a period of 96 months and 17 months to date, respectively. Conclusion: Despite of the fatal damage to according organs and tissue, it suggest that aGVHD in liver recipients of HCC may also develop a GVT effect and benefit prophylaxis of tumor recurrence and result in a long-term healthy recipients survival. |
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