| Dongliang Pan,Liming Dong,Lianchao Jin,Bing Yang,Zhe Zhou,Kai Zhang,Xianghua Zhang,Ningchen Li. Serum testosterone suppression and potential for agonistic stimulation during chronic treatment with monthly depot formulation of domestic substitute of leuprorelin acetate microspheres for metastatic prostate cancer. Oncol Transl Med, 2014, 13: 320-322. |
| Serum testosterone suppression and potential for agonistic stimulation during chronic treatment with monthly depot formulation of domestic substitute of leuprorelin acetate microspheres for metastatic prostate cancer |
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| KeyWord:prostatic neoplasms, metastatic; testosterone; leuprorelin; domestic substitute |
| Author Name | Affiliation | | Dongliang Pan | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100144, China | | Liming Dong | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100145, China | | Lianchao Jin | Department of Urology, Weihai Wendeng Center Hospital, Shandong 264400, China | | Bing Yang | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100147, China | | Zhe Zhou | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100148, China | | Kai Zhang | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100149, China | | Xianghua Zhang | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100150, China | | Ningchen Li | Department of Urology, Peking University Shougang Hospital
Wujieping Urology Medical Center of Peking
University, Beijing 100151, China |
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| Abstract: |
| Objective: We aimed to evaluate the efficiency of serum testosterone suppression as well as the potential for agonistic stimulation of serum testosterone during chronic treatment with monthly (3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres for patients with metastatic prostate cancer. Methods: A total of 23 patients with metastatic prostate cancer were enrolled in the prospective study and received 6 monthly intramuscular depot injections of domestic substitute of leuprorelin acetate microspheres. Their levels and patterns of serum testosterone suppression and the potential for agonistic stimulation of serum testosterone were monitored following injection monthly (3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres for 24 weeks. Results: Mean testosterone was 431.4 ng/dL, 119.3 ng/dL, 28.2 ng/dL by week 1, 2, 3 and decreased to less than 15.6 ng/dL by week 4 where it remained throughout the treatment period. Median time to suppression of serum testosterone was 20.7 days. No transient minor “escape” from suppression occurred in all patients which was defined as a single testosterone value greater than 50 ng/dL once suppression was achieved. Assessment of agonistic stimulation following the second depot injection revealed no pattern of stimulation. Conclusion: We concluded that monthly (3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres could provide persistent, stable suppression of serum testosterone throughout the dosing intervals, and that the initial depot injection of this formulation also could provide sufficient pituitary desensitization to prevent agnostic stimulation of serum testosterone during chronic treatment. |
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