| Junping Xu,Hongsheng Yu. Relationship between expression of ER, PR, Her-2, Ki-67 and neoadjuvant chemotherapy effect in breast cancer. Oncol Transl Med, 2014, 13: 220-223. |
| Relationship between expression of ER, PR, Her-2, Ki-67 and neoadjuvant chemotherapy effect in breast cancer |
| |
| View Full Text View/Add Comment Download reader |
| KeyWord:breast cancer; neoadjuvant chemotherapy; estrogen receptor (ER); progestogen receptor (PR); human epidermal growth factor receptor (Her-2); Ki-67 |
| Author Name | Affiliation | | Junping Xu | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China | | Hongsheng Yu | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266004, China |
|
| Hits: 7543 |
| Download times: 7964 |
| Abstract: |
| Objective: The purpose of the study was to investigate the relationship between the expression of estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor (Her-2), Ki-67 and the effect of neoadjuvant chemotherapy in breast cancer. Methods: The expression of ER, PR, Her-2 and Ki-67 in 45 breast cancers which received neoadjuvant chemotherapy was detected by immunohistochemistry. Results: The effective rates in ER negative and PR negative groups were higher than those in ER positive and PR positive groups (83.3% vs 59. 4%, 82.4% vs 60.6%). There was no significant difference of the effective rate between Her-2 overexpressed group and Her-2 non-overexpressed group (81.8% vs 64.1%), and the same thing happened between Ki-67 negative group and Ki-67 positive group (67.7% vs 63.2%). Conclusion: In the patients with breast cancer, ER, PR negative ones were more sensitive to neoadjuvant chemotherapy. These patients may get more benefits from chemotherapy. ER, PR could be feasible markers for predicting the effective rate of neoadjuvant chemotherapy. |
| Close |
|
|
|