| Baoping Chang,Xiao Wang,Songsou Gao,Bianfeng Zhao,Wanli Wang,Shaohua Yang,Shiying Yu. Clinical signification of high-mobility group box 1protein (HMGB1) expression in infiltrating ductalcarcinoma breast tissue. Oncol Transl Med, 2014, 13: 215-219. |
| 乳腺浸润性导管癌组织中HMGB1表达的临床意义 |
| Clinical signification of high-mobility group box 1protein (HMGB1) expression in infiltrating ductalcarcinoma breast tissue |
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| DOI： |
| 中文关键词: 乳腺浸润性导管癌，高迁移率族蛋白（HMGB1），临床分期, 淋巴结, ER， HER-2 |
| 英文关键词: infiltrating ductal carcinoma (IDC); high-mobility group box 1 protein (HMGB1); clinical staging; lymph node; estrogen receptor (ER); human epidermal growth factor receptor 2 (HER-2) |
| 基金项目: |
| Author Name | Affiliation | | Baoping Chang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan 430030, China | | Xiao Wang | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471001, China | | Songsou Gao | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471002, China | | Bianfeng Zhao | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471003, China | | Wanli Wang | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471004, China | | Shaohua Yang | KingMed Diagnostics, Zhengzhou 450000, China | | Shiying Yu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan 430038, China |
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| 中文摘要: |
| 目的：探讨HMGB1表达在乳腺浸润性导管癌组织中的临床意义。方法：采用免疫组织化学（Immunohistochmeistry,IHC）方法检测乳腺浸润性导管癌患者癌组织中HMGB1蛋白的表达并分析其表达与肿瘤组织大小、淋巴结转移、临床分期、ER、PR、HER-2的关系。结果：60例乳腺浸润性导管癌组织中HMGB1表达呈阳性或强阳性46例（76.67），HMGB1表达与临床分期、淋巴结有无转移有显著统计学差异（P＜0.01），HMGB1表达与乳腺浸润性导管癌ER、HER-2表达有统计学差异（P＜0.05），但HMGB1表达与肿瘤组织大小、PR表达无统计学差异（P＞0.05）。spearman相关性分析表明HMGB1表达与ER存在负相关,与临床分期、淋巴结转移、HER-2存在正相关。结论：HMGB1蛋白有望成为乳腺浸润性导管癌预后不良的生物学指标之一。 |
| 英文摘要: |
| Objective: Exploring the clinical signification of high-mobility group box 1 protein (HMGB1) expression in infiltrating ductal carcinoma (IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) were also analyzed. Results: Forty-six cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression (76.67%), statistical significance was observed between HMGB1 expression with clinical staging (P < 0.01), lymph node metastasis (P < 0.01), breast cancer ER (P < 0.05) and HER-2 (P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression (P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It’s promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis. |
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