| Xiangqian Lu,Xiao Li,Fangzhen Shen,Wenjing Xiao. Vasculogenic mimicry in non-small cell lung cancer and its relationship with tumor stage. Oncol Transl Med, 2014, 13: 207-211. |
| 血管生成拟态的生成与非小细胞肺癌肿瘤分期之间关系的研究 |
| Vasculogenic mimicry in non-small cell lung cancer and its relationship with tumor stage |
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| DOI： |
| 中文关键词: |
| 英文关键词: vasculogenic mimicry (VM); angiogenesis; non-small cell lung cancer (NSCLC); targeted therapy; microvessel density (MVD) |
| 基金项目: |
| Author Name | Affiliation | | Xiangqian Lu | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China | | Xiao Li | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266004, China | | Fangzhen Shen | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266005, China | | Wenjing Xiao | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266006, China |
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| 中文摘要: |
| 目的: 探讨血管生成拟态的生成与非小细胞肺癌肿瘤分期之间的关系。方法: 收集42例非小细胞肺癌组织切片， 19例患者为早期（ Ⅰ+Ⅱ ），其余23例为晚期（ Ⅲ+Ⅳ） 。此外，20例为手术治疗后的患者，22例接收了化疗治疗。通过研究血管生成拟态与肿瘤分期，化疗效果，HIF-1α， MVD与临床病理特征的关系。结果：肿瘤早期患者血管生成拟态的表达显著高于晚期（ 68.4 ％ VS 26.1 ％ ， P = 0.006 ） ，血管生成拟态和HIF-1α阳性表达率有一定关系（ P = 0.034） 。但血管生成拟态的表达与化疗效果（ 14.3 ％ VS 26.7 ％ ， P = 1.00）或MVD 的表达（ P> 0.05）关系不显著。我们发现血管生成拟态的表达与远处转移和淋巴结转移（ P <0.05）呈负相关，但是和临床病理类型无相关性。结论：血管生成拟态的表达在非小细胞肺癌患者的早期阶段和淋巴结转移有一定的相关性 。随着病情的进展，血管生成拟态可能会由血管内皮细胞所取代，因此，晚期患者尤其是有远处转移的患者几乎无血管生成拟态的表达。乏氧环境的存在，HIF-1α可能使得血管生成拟态表达出现差异。因此，我们推断血管生成拟态可能成为肺癌靶向治疗的新靶点，并可能为临床分期和治疗提供帮助。 |
| 英文摘要: |
| Objective: The purpose of the study was to study the mechanism of vasculogenic mimicry (VM) and its relationship with tumor stage in non-small cell lung cancer (NSCLC). Methods: Forty-two patients with NSCLC were collected, 19 belonged to the early stage (stages I + II) while 23 were late stage (stages III + IV). Moreover, 20 patients got surgical treatment and 22 got chemotherapy. We studied the relationship of VM with stage, chemotherapeutic effect, HIF-1α, microvessel density (MVD) and clinicopathologic features. Results: VM in patients of early stages were significantly more than late stages (68.4% vs 26.1%, P = 0.006), and the positive rate of VM was proportional to HIF-1α (P = 0.034). But no correlation was found between VM and chemotherapeutic effect (14.3% vs 26.7%, P = 1.00) or MVD (P > 0.05). Furthermore, we found VM also showed a negative correlation with distant metastases and lymph nodes metastases (P < 0.05) while no correlation was found with other clinicopathologic. Conclusion: VM was generated during the early stage in NSCLC and correlated with lymph nodes metastases. As the disease progressed, VM may be replaced by vascular endothelial cells, so the late-stage patients especially people with distant metastases had fewer VM. As the main factor produced by hypoxia, HIF-1α may make a difference in VM formation. Thus we inferred VM might be a new target for targeted therapy, and could provide help for clinical staging and treatment. |
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