| Xiangqian Lu,Xiao Li,Fangzhen Shen,Wenjing Xiao. Vasculogenic mimicry in non-small cell lung cancer and its relationship with tumor stage. Oncol Transl Med, 2014, 13: 207-211. |
| Vasculogenic mimicry in non-small cell lung cancer and its relationship with tumor stage |
| |
| View Full Text View/Add Comment Download reader |
| KeyWord:vasculogenic mimicry (VM); angiogenesis; non-small cell lung cancer (NSCLC); targeted therapy; microvessel density (MVD) |
| Author Name | Affiliation | | Xiangqian Lu | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China | | Xiao Li | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266004, China | | Fangzhen Shen | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266005, China | | Wenjing Xiao | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266006, China |
|
| Hits: 7909 |
| Download times: 7773 |
| Abstract: |
| Objective: The purpose of the study was to study the mechanism of vasculogenic mimicry (VM) and its relationship with tumor stage in non-small cell lung cancer (NSCLC). Methods: Forty-two patients with NSCLC were collected, 19 belonged to the early stage (stages I + II) while 23 were late stage (stages III + IV). Moreover, 20 patients got surgical treatment and 22 got chemotherapy. We studied the relationship of VM with stage, chemotherapeutic effect, HIF-1α, microvessel density (MVD) and clinicopathologic features. Results: VM in patients of early stages were significantly more than late stages (68.4% vs 26.1%, P = 0.006), and the positive rate of VM was proportional to HIF-1α (P = 0.034). But no correlation was found between VM and chemotherapeutic effect (14.3% vs 26.7%, P = 1.00) or MVD (P > 0.05). Furthermore, we found VM also showed a negative correlation with distant metastases and lymph nodes metastases (P < 0.05) while no correlation was found with other clinicopathologic. Conclusion: VM was generated during the early stage in NSCLC and correlated with lymph nodes metastases. As the disease progressed, VM may be replaced by vascular endothelial cells, so the late-stage patients especially people with distant metastases had fewer VM. As the main factor produced by hypoxia, HIF-1α may make a difference in VM formation. Thus we inferred VM might be a new target for targeted therapy, and could provide help for clinical staging and treatment. |
| Close |
|
|
|