| Jing Song,Zhiliang Liu,Lilin He,Wei Luo,Huilin Xu,Pingpo Ming,Wei Ge. Clinical observation of platinum-based chemotherapy combined with concurrent three-dimensional conformal radiotherapy in patients with locally advanced non-small cell lung cancer. Oncol Transl Med, 2014, 13: 199-202. |
| 含铂方案同步三维适形放疗治疗
局部晚期非小细胞肺癌78例临床观察 |
| Clinical observation of platinum-based chemotherapy combined with concurrent three-dimensional conformal radiotherapy in patients with locally advanced non-small cell lung cancer |
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| DOI： |
| 中文关键词: 顺铂；放化疗；非小细胞肺癌；三维适形；影像融合 |
| 英文关键词: cisplatin; chemo-radiotherapy; non-small-cell lung cancer; three-dimensional conformal; image fusion |
| 基金项目: |
| Author Name | Affiliation | | Jing Song | Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China | | Zhiliang Liu | Department of Oncology, Tianmen First People's Hospital, Tianmen 431700, China | | Lilin He | Department of Oncology, Tianmen First People's Hospital, Tianmen 431701, China | | Wei Luo | Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430063, China | | Huilin Xu | Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430064, China | | Pingpo Ming | Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430065, China | | Wei Ge | Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430066, China |
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| 中文摘要: |
| 目的 探讨含铂方案同步放化疗治疗局部晚期非小细胞肺癌的近期疗效。方法 2006-2010年使用含铂方案同步三维适形放疗的局部晚期非小细胞肺癌患者78例。三维适形放疗，胸部CT定位时行吸气末和呼气末二次扫描，数据传输至TPS上进行图像融合，在融合的图像上进行靶区勾画，放疗第一天开始行化疗。同步放化疗结束后4-6周进行全面复查，评价近期疗效。结果 CR 8例，PR54例，有效率79.5%。Ⅲ-Ⅳ级放射性食管炎发生率11.5%。治疗过程中无退出及死亡病例。结论 同步放化疗可显著提高Ⅲ期NSCLC近期疗效，延长生存期，且不良反应患者可以耐受。 |
| 英文摘要: |
| Objective: The aim of our study was to explore the short-term efficacy of platinum-based combined with concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer (NSCLC). Methods: Between 2006 to 2010, 78 cases of locally advanced NSCLC were enrolled into this trial. All patients were given platinum-based chemotherapy combined with concurrent three-dimensional conformal radiotherapy (3-DCRT). Chest CT scans were obtained during end-expiratory and end-inspiratory pauses when performing positioning. Image fusion was done after the image data was transferred to treatment plan system (TPS). The target volume was delineated on the fusion images. The chemotherapy was given on the first day of radiotherapy. Comprehensive examinations were conducted 4–6 weeks after concurrent chemoradiotherapy to assess short-term efficacy. Results: Complete remission (CR) was achieved in 8 cases and partial remission (PR) in 54 cases. The efficiency rate reached 79.5%. Grade III–IV radiation esophagitis occurred in 11.5%. No exit and death cases during treatment. Conclusion: Concurrent chemo-radiotherapy could significantly improve the short-term efficacy and prolong survival of stage III NSCLC, meanwhile the adverse reactions could be tolerated. |
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