| Xiaojun Deng,Jianwei Cao,Feng Liu,Weifeng Wang,Jidong Hao,Jiansheng Wan,Hui Liu. Optimizing prostate biopsy for repeat transrectal prostate biopsies patients. Oncol Transl Med, 2014, 13: 174-176. |
| Optimizing prostate biopsy for repeat transrectal prostate biopsies patients |
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| KeyWord:biopsy; prostate cancer; detection rate |
| Author Name | Affiliation | | Xiaojun Deng | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201318, China | | Jianwei Cao | Department of Urology, Military 411 Hospital, Shanghai 200081, China | | Feng Liu | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201320, China | | Weifeng Wang | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201321, China | | Jidong Hao | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201322, China | | Jiansheng Wan | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201323, China | | Hui Liu | Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201324, China |
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| Abstract: |
| Objective: Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer remains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods: In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45° angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontally inwardly inclined 45°. Results: A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8% (8/45), and prostate intraepithelial neoplasm (PIN) was 6.7% (3/45). The patients receiving repeat transrectal prostate biopsies were pathologically diagnosed as lower Gleason grade prostate cancers. Conclusion: The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrectal prostate biopsies patients. |
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