Shuguo Wang,Haixia Wang,Ping Sui,Bo Han. Gastric signet-ring cell carcinoma with paraneoplastic eosinophilia: A case report and literature review. Oncol Transl Med, 2022, 8: 264-266.
Gastric signet-ring cell carcinoma with paraneoplastic eosinophilia: A case report and literature review
Received:August 04, 2022  Revised:October 13, 2022
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KeyWord:eosinophilia; paraneoplastic syndrome; gastric signet-ring cell carcinoma
Author NameAffiliationE-mail
Shuguo Wang Qingdao Municipal Hospital shuguo_wang@163.com 
Haixia Wang Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)  
Ping Sui The Affiliated Yantai Yuhuangding Hospital of Qingdao University  
Bo Han Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital) hbdoctor@126.com 
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Abstract:
      We report the case of a 40-year-old female Chinese patient with gastric signet-ring cell carcinoma that was first diagnosed because of paraneoplastic eosinophilia. The patient’s eosinophil count reduced markedly to normal levels within 24 h after radical gastrectomy and Billroth II anastomosis. The patient recovered well after the surgery and no abnormalities were found during the regular follow-ups. Paraneoplastic eosinophilia is an unusual manifestation that usually remains asymptomatic; moreover, cases of solid malignant tumors with eosinophilia are uncommon. To our knowledge, this is the first reported case of paraneoplastic eosinophilia in a patient with gastric carcinoma. We considered eosinophilia as a manifestation of a paraneoplastic syndrome, which can be the first clinical manifestation of a malignancy.
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