Zhihua Wang. Metabolic reprogramming drives homeostasis and specialization of regulatory T cells in cancer. Oncol Transl Med, 2022, 8: 18-27.
Metabolic reprogramming drives homeostasis and specialization of regulatory T cells in cancer
Received:February 10, 2022  Revised:February 10, 2022
View Full Text  View/Add Comment  Download reader
KeyWord:cancer immunity; FOXP3; T cells; tumor microenvironment
Author NameAffiliationE-mail
Zhihua Wang Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China zhwang_hust@hotmail.com 
Hits: 2404
Download times: 2696
Abstract:
      Transcription factor forkhead box P3 (Foxp3)+ regulatory T (Treg) cells are receiving increasing attention because this unique subset of T cells is characterized by exerting negative regulatory function of cellular immune responses. The resultant suppression of anti-tumor immunity in the tumor microenvironment (TME) is regarded as a major obstacle to immunotherapies in a plethora of cancers. Thus, an integrated understanding of the intrinsic correlation between tumors and Treg cell biology is urgently required. This review focuses on the peculiar biochemical effects of tumor metabolic environments on Tregs and how Tregs orchestrate internal metabolic switches and altered metabolic pathways and molecules to survive and function after the remodeling of homeostasis and specialization, providing new directions for immunotherapies.
Close