| Yijun Wang,Limin Xia,Mengyu Sun,Tongyue Zhang,Yangyang Feng,Xiangyuan Luo,Meng Xie,Xiaoyu Ji,Danfei Liu,Wenjie Huang. Role of chemokines in the hepatocellular carcinoma microenvironment and their translational value in immunotherapy. Oncol Transl Med, 2022, 8: 1-17. |
| Role of chemokines in the hepatocellular carcinoma microenvironment and their translational value in immunotherapy |
| Received:February 07, 2022 Revised:February 07, 2022 |
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| KeyWord:hepatocellular carcinoma; chemokine; chemokine receptor; tumor microenvironment; immune therapy; therapeutic target |
| Author Name | Affiliation | Department | | Yijun Wang | Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | Department of Gastroenterology | | Limin Xia | Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | Department of Gastroenterology, Institute of Liver | | Mengyu Sun | Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | Department of Gastroenterology | | Tongyue Zhang | Department of Gastroenterology | Department of Gastroenterology | | Yangyang Feng | Department of Gastroenterology | Department of Gastroenterology | | Xiangyuan Luo | Department of Gastroenterology | Department of Gastroenterology | | Meng Xie | Department of Gastroenterology | Department of Gastroenterology | | Xiaoyu Ji | Department of Gastroenterology | Department of Gastroenterology | | Danfei Liu | Department of Gastroenterology | Department of Gastroenterology | | Wenjie Huang | Hepatic Surgery Center, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital | Hepatic Surgery Center, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital |
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| Abstract: |
| The difficulty of early diagnosis, high tumor heterogeneity, and high recurrence and metastasis rates lead
to an unsatisfactory treatment status for hepatocellular carcinoma (HCC). HCC is a typical inflammationdriven tumor. Chronic inflammation allows nascent tumors to escape immunosurveillance. Chemokines
are small, soluble, secreted proteins that can regulate the activation and trafficking of immune cells during
inflammation. Several studies have shown that various chemokines with overarching functions disrupt the
immune microenvironment during the initiation and progression of HCC. The dysregulated chemokine
network in HCC contributes to multiple malignant processes, including angiogenesis, tumor proliferation,
migration, invasion, tumor low response, and resistance to immune therapy. Here, we summarize the current
studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,
highlighting potential translational therapeutic uses for modulating the chemokine system in HCC. |
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