| Shuang Chen,Yongchu Huang,Yuchun Cao,Yong Zhang. Nasal-type extranodal NK/T cell lymphoma in association with hemophagocytic syndrome: a case report and literature review. Oncol Transl Med, 2022, 8: 104-108. |
| Nasal-type extranodal NK/T cell lymphoma in association with hemophagocytic syndrome: a case report and literature review |
| Received:November 29, 2021 Revised:April 19, 2022 |
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| KeyWord:lymphoma; non-Hodgkin; lymphohistiocytosis; hemophilic |
| Author Name | Affiliation | E-mail | | Shuang Chen | Department of Dermatology and Venereology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 1361421624@qq.com | | Yongchu Huang | Department of Dermatology and Venereology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Yuchun Cao | Department of Dermatology and Venereology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Yong Zhang | Department of Dermatology and Venereology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 61112426@qq.com |
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| Abstract: |
| We present a rare case of nasal-type CD56-negative NK/T-cell lymphoma. The patient developed
hemophagocytic syndrome during diagnosis and treatment. The patient presented to our hospital (Tongji
Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) with
“nasal congestion for 3 months and scattered erythema, nodules, and ulcers all over the body for 1 month.”
We analyzed clinical manifestations, skin histopathology, immunohistochemistry, and in situ hybridization
results. Histopathology of the skin revealed a moderate amount of atypical lymphocyte infiltration between
the entire dermis and collagen bundles. Immunohistochemistry showed the following: CD30 (+), TIA-1
(+), CD3(2GV6) (+), CD5 part (+), CD8 part (+), CD43 (+), CD56 (–), CD4 (–), CD20 (–), PAX5 (–), PCK
(–), P63 (–), P40 (–), EGFR (–), Ki-67 (the hot spot LI is approximately 80%), and in situ hybridization
EBER-ROCH (+). The diagnosis made was “NK/T cell lymphoma nasal type”. This type of lymphoma is
aggressive, progresses quickly, and has a poor prognosis. Early clinical manifestations are extremely
atypical, especially in the absence of rash. Analysis of the skin manifestations of the disease has a positive
effect on its early diagnosis, early treatment, and prognosis. |
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