| Sisi Wang,Chuyang Lin (Co-first author),Chuyang Lin,Tingting Xi,Yu Tong,Jinlin Wu. Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis. Oncol Transl Med, 2022, 8: 217-225. |
| Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis |
| Received:October 11, 2021 Revised:October 10, 2022 |
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| KeyWord:IKZF1; gene polymorphism; acute lymphoblastic leukemia (ALL); meta-analysis; systematic reviews; case-control study |
| Author Name | Affiliation | E-mail | | Sisi Wang | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | wssmeitan@163.com | | Chuyang Lin (Co-first author) | | | | Chuyang Lin | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Tingting Xi | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Yu Tong | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Jinlin Wu | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | wujl_2000@sina.com |
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| Abstract: |
| Objective The aim of the study was to systematically evaluate the correlation between IKZF1
polymorphisms and the risk of acute lymphoblastic leukemia.
Methods Computer databases including PubMed, EMBASE, and Web of Science were searched for
case-control studies on the association between IKZF1 polymorphisms and the risk of acute lymphoblastic
leukemia. The retrieval period was from the establishment of the database to November 2020. Two
researchers independently screened the literature, extracted the data, evaluated the risk of bias in the
included studies, and used Stata 14.0 software for meta-analysis.
Results A total of 48 case-control studies were included, with 10 520 and 44 049 cases in the case and
control groups, respectively. The meta-analysis results showed that rs4132061 and rs11978267 of IKZF1
were significantly correlated with the risk of acute lymphoblastic leukemia (ALL).
Conclusion Current evidence indicates that rs4132061 and rs11978267 of IKZF1 are significantly
associated with the risk of B-cell ALL. |
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