| huang. Effect of postoperative adjuvant chemotherapy on the prognosis of patients with ypT0-3N0 rectal cancer undergoing neoadjuvant chemoradiotherapy. Oncol Transl Med, 2023, 9: 43-48. |
| Effect of postoperative adjuvant chemotherapy on the prognosis of patients with ypT0-3N0 rectal cancer undergoing neoadjuvant chemoradiotherapy |
| Received:September 27, 2021 Revised:May 19, 2022 |
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| KeyWord:rectal cancer; postoperative adjuvant chemotherapy; neoadjuvant chemoradiotherapy; total mesorectal excision |
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| Abstract: |
| Objective The aim of this study was to investigate the effect of adjuvant chemotherapy (AC) on the
prognosis of patients with ypT0-3N0 rectal cancer undergoing neoadjuvant chemoradiotherapy.
Methods The study participants were 110 patients with locally advanced rectal cancer. Thirty-four
patients did not receive postoperative AC treatment, and the other 76 patients received postoperative AC
treatment. The differences in the 5-year overall survival (OS) and disease-free survival (DFS) between the
two groups were compared.
Results Age was an important determinant of the patients’ decision to undergo postoperative treatment.
Patients who did not receive AC treatment were significantly older than those who received AC treatment
(P < 0.05). The tumor location (distance above anal margin) in the AC group was significantly larger than
that in the non-AC group (P < 0.05). Moreover, there was no significant difference in the 5-year DFS and
OS between the two groups. Postoperative AC did not significantly improve the prognosis of patients with
rectal cancer. Age, tumor differentiation, and the number of resected lymph nodes were independent factors
affecting the OS of patients (P < 0.05). Older patients, patients with lower degree of tumor differentiation,
and patients with <12 resected lymph nodes showed worse prognosis (P < 0.05).
Conclusion Patients with rectal cancer whose ypT0-3N0 stage is reduced after neoadjuvant
chemoradiotherapy, especially those without adverse prognostic factors, do not need AC after surgery. |
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