| Li Zheng,Jin Wang,Lin Ang,Jin Huang,Min Zhao. Spindle epithelial tumor with thymus-like differentiation：A case report and literature review. Oncol Transl Med, 2022, 8: 150-153. |
| Spindle epithelial tumor with thymus-like differentiation：A case report and literature review |
| Received:September 11, 2021 Revised:May 27, 2022 |
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| KeyWord:spindle epithelial tumor; thymus-like differentiation; immunohistochemistry |
| Author Name | Affiliation | E-mail | | Li Zheng | The Second People’s Hospital of Hefei | zhengli352@163.com | | Jin Wang | The Second People’s Hospital of Hefei | | | Lin Ang | The Second People’s Hospital of Hefei | | | Jin Huang | The Second People’s Hospital of Hefei | | | Min Zhao | The Second People’s Hospital of Hefei | Zhao.Min.hi@163.com |
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| Abstract: |
| Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare, low-grade malignant neoplasm
that mainly occurs in the thyroid gland or its perimeter. Fewer than 10 cases of SETTLE have been reported
in the Chinese literature, whereas approximately 50 cases have been reported in the international literature.
We report a rare case of SETTLE that occurred in the soft tissues of the neck around the thyroid gland in a
41-year-old man. The neoplastic tissue, which mainly consisted of spindle epithelial components, included
sporadically visible thymus-like structures. Immunohistochemistry demonstrated CK and CK19 positivity
in the thymic epithelial components and CK, vimentin, and Bcl-2 positivity in the spindle cells. Surgical
resection is the main treatment option for SETTLE. This patient underwent mass resection of the neck, and
no recurrence or metastasis was observed even at 8 months postoperatively |
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