Li Zheng,Jin Wang,Lin Ang,Jin Huang,Min Zhao. Spindle epithelial tumor with thymus-like differentiation:A case report and literature review. Oncol Transl Med, 2022, 8: 150-153.
Spindle epithelial tumor with thymus-like differentiation:A case report and literature review
Received:September 11, 2021  Revised:May 27, 2022
View Full Text  View/Add Comment  Download reader
KeyWord:spindle epithelial tumor; thymus-like differentiation; immunohistochemistry
Author NameAffiliationE-mail
Li Zheng The Second People’s Hospital of Hefei zhengli352@163.com 
Jin Wang The Second People’s Hospital of Hefei  
Lin Ang The Second People’s Hospital of Hefei  
Jin Huang The Second People’s Hospital of Hefei  
Min Zhao The Second People’s Hospital of Hefei Zhao.Min.hi@163.com 
Hits: 260
Download times: 365
Abstract:
      Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare, low-grade malignant neoplasm that mainly occurs in the thyroid gland or its perimeter. Fewer than 10 cases of SETTLE have been reported in the Chinese literature, whereas approximately 50 cases have been reported in the international literature. We report a rare case of SETTLE that occurred in the soft tissues of the neck around the thyroid gland in a 41-year-old man. The neoplastic tissue, which mainly consisted of spindle epithelial components, included sporadically visible thymus-like structures. Immunohistochemistry demonstrated CK and CK19 positivity in the thymic epithelial components and CK, vimentin, and Bcl-2 positivity in the spindle cells. Surgical resection is the main treatment option for SETTLE. This patient underwent mass resection of the neck, and no recurrence or metastasis was observed even at 8 months postoperatively
Close