| zhangyichao. Prognostic value of serum carcinoembryonic antigen combined with nutritional status control score in patients with colorectal cancer. Oncol Transl Med, 2022, 8: 135-139. |
| Prognostic value of serum carcinoembryonic antigen combined with nutritional status control score in patients with colorectal cancer |
| Received:September 03, 2021 Revised:May 19, 2022 |
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| KeyWord:colorectal cancer; carcinoembryonic antigen; nutritional status control score |
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| Abstract: |
| Objective To investigate the prognostic value of serum carcinoembryonic antigen (CEA) and controlling
nutritional status (CONUT) score in patients with colorectal cancer.
Methods We retrospectively studied 261 patients with colorectal cancer in our hospital. The patients were
divided into two groups by CONUT = 3 and CEA = 5 ng/mL, and the effects of CONUT score and CEA level
on the prognosis and clinicopathological parameters were statistically analyzed.
Results (1) Different CONUT scores were significantly correlated with age, tumor diameter, differentiation
type, and T stage (P < 0.05). The older the patient was, the larger the tumor diameter, undifferentiated
tumor, and T stage were, the higher the CONUT score was. (2) Seventy-five patients died during the
follow-up period, and 45 patients died of progression or recurrence of colorectal cancer. The 5-year overall
survival (OS) rate of the low CONUT score group was significantly higher than that of the high CONUT
score group, and the 5-year OS rate of the low CEA group was significantly higher than that of the high
CEA group; the difference was statistically significant (P < 0.01). (3) According to the serum CEA level
and CONUT score, the 5-year survival rates of CEAlow/CONUTlow, CEAlow/CONUThigh, CEAhigh/CONUTlow,
and CEAhigh/CONUThigh were 84.7%, 69%, 55.3%, and 36.1% respectively, with statistical significance (P
<0.01). (4) The Cox multivariate analysis showed that age, CONUT score, CEA combined with CONUT
score, lymph node metastasis, and distant metastasis were independent risk factors for the prognosis of
colorectal cancer patients.
Conclusion: The combination of CEA detection and CONUT score can more accurately judge the prognosis
of colorectal cancer patients. |
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