| Feifei Tan,Zhongyin Zhou. Autophagy-related lncRNA and its related mechanism in colon adenocarcinoma. Oncol Transl Med, 2021, 7: 305-313. |
| Autophagy-related lncRNA and its related mechanism in colon adenocarcinoma |
| Received:May 25, 2021 Revised:December 10, 2021 |
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| KeyWord:colon adenocarcinoma (COAD); prognostic model; long noncoding RNA (lncRNA); EB1-AS1 |
| Author Name | Affiliation | E-mail | | Feifei Tan | Renmin Hospital of Wuhan University, Hubei Key Laboratory of Digestive System, Wuhan 430060, China | atanfeifei@163.com | | Zhongyin Zhou | Renmin Hospital of Wuhan University, Hubei Key Laboratory of Digestive System, Wuhan 430060, China | 13871029766@163.com |
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| Abstract: |
| Objective Colon cancer is a type of cancer with high morbidity and mortality, of which adenocarcinoma
is the most common type. Numerous studies have found that long noncoding RNAs (lncRNAs) are related
to the occurrence and development of colon cancer. Autophagy is a key metabolic process in the human
body and has a role in affecting cancer growth. In this study, our aim was to explore the correlation between
lncRNAs and colon adenocarcinoma (COAD) from the perspective of autophagy.
Methods A series of bioinformatics methods were used to explore the correlation between lncRNA and
COAD from the perspective of autophagy.
Results Four autophagy-related lncRNAs related to the prognosis of COAD were identified: EB1-AS1,
LINC02381, AC011462.4, and AC016876.1. These four lncRNAs may act as oncogenes involved in the
occurrence and development of COAD. The prognostic model was established, and the accuracy of
the model was verified by the receiver operating characteristic curve. The risk score of the model could
independently predict the prognosis of patients and was preferable to other clinical indicators, with higher
values indicating a worse prognosis of the patients. Gene Set Enrichment Analysis was performed for
these four lncRNAs, which showed that the high expression group of these were enriched in the basal cell
carcinoma pathway. To make it more convenient for clinicians to use, we constructed a nomogram based on
age and risk score, which can be used to evaluate the one-, three-, and five-year survival rates of patients.
Conclusion These results can help us understand the mechanism of action of lncRNA on COAD from
the perspective of autophagy and may provide new directions for the diagnosis and treatment of COAD.
The EB1-AS1 gene in this study is a potential candidate biological target for COAD treatment in the future.. |
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