| Yuxue Wei,Hua Yang,Xiaoqiu Liu. Diagnostic value of LncRNAs as a potential biomarker for oral squamous cell carcinoma diagnosis: a meta-analysis for oral squamous cell carcinoma diagnosis: a meta-analysis. Oncol Transl Med, 2021, 7: 123-129. |
| Diagnostic value of LncRNAs as a potential biomarker for oral squamous cell carcinoma diagnosis: a meta-analysis for oral squamous cell carcinoma diagnosis: a meta-analysis |
| Received:March 24, 2021 Revised:June 16, 2021 |
| View Full Text View/Add Comment Download reader |
| KeyWord:lncRNA; oral squamous cell carcinoma; diagnosis; meta-analysis |
| Author Name | Affiliation | E-mail | | Yuxue Wei | People''s Hospital of Lanling County | yuxuewei1990@gmail.com | | Hua Yang | People''s Hospital of Lanling County | | | Xiaoqiu Liu | Department of Stomatology, People''s Hospital of Lanling County, Linyi 276000, China | liuxq6399@163.com |
|
| Hits: 3421 |
| Download times: 3628 |
| Abstract: |
| Objective Several studies have revealed the critical role of long non-coding RNAs (lncRNAs) as
biomarkers for diagnosing oral squamous cell carcinoma (OSCC). However, the data remain inconsistent.
This meta-analysis was performed to summarize the potential of lncRNAs as OSCC biomarkers.
Methods We searched PubMed, Cochrane Library, Web of Science, and China National Knowledge
Infrastructure databases for literature published until December 10, 2020. Study quality was assessed
using Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, and other
measures regarding lncRNAs for OSCC diagnosis were pooled using bivariate meta-analysis models. Data
analyses were performed using STATA 14.0.
Results Overall, 8 studies with 981 cases and 585 controls were included in the pooled analysis. The
pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and
area under the receiver operating characteristic curve values were as follows: 0.76 [95% confidence
interval (CI), 0.65–0.84], 0.90 (95% CI, 0.82–0.95), 7.5 (95% CI, 4.20–13.40), 0.27 (95% CI, 0.18–0.39),
28 (95% CI, 13.00–58.00), 0.90 (95% CI, 0.87–0.93), respectively. Deeks’ funnel plot asymmetry test (P =
0.56) indicated no potential publication bias.
Conclusion Our meta-analytical evidence suggests that lncRNAs could be employed as a potential noninvasive diagnostic tool for OSCC. |
| Close |
|
|
|