Yuxue Wei,Hua Yang,Xiaoqiu Liu. Diagnostic value of LncRNAs as a potential biomarker for oral squamous cell carcinoma diagnosis: a meta-analysis for oral squamous cell carcinoma diagnosis: a meta-analysis. Oncol Transl Med, 2021, 7: 123-129.
Diagnostic value of LncRNAs as a potential biomarker for oral squamous cell carcinoma diagnosis: a meta-analysis for oral squamous cell carcinoma diagnosis: a meta-analysis
Received:March 24, 2021  Revised:June 16, 2021
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KeyWord:lncRNA; oral squamous cell carcinoma; diagnosis; meta-analysis
Author NameAffiliationE-mail
Yuxue Wei People''s Hospital of Lanling County yuxuewei1990@gmail.com 
Hua Yang People''s Hospital of Lanling County  
Xiaoqiu Liu Department of Stomatology, People''s Hospital of Lanling County, Linyi 276000, China liuxq6399@163.com 
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Abstract:
      Objective Several studies have revealed the critical role of long non-coding RNAs (lncRNAs) as biomarkers for diagnosing oral squamous cell carcinoma (OSCC). However, the data remain inconsistent. This meta-analysis was performed to summarize the potential of lncRNAs as OSCC biomarkers. Methods We searched PubMed, Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases for literature published until December 10, 2020. Study quality was assessed using Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, and other measures regarding lncRNAs for OSCC diagnosis were pooled using bivariate meta-analysis models. Data analyses were performed using STATA 14.0. Results Overall, 8 studies with 981 cases and 585 controls were included in the pooled analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the receiver operating characteristic curve values were as follows: 0.76 [95% confidence interval (CI), 0.65–0.84], 0.90 (95% CI, 0.82–0.95), 7.5 (95% CI, 4.20–13.40), 0.27 (95% CI, 0.18–0.39), 28 (95% CI, 13.00–58.00), 0.90 (95% CI, 0.87–0.93), respectively. Deeks’ funnel plot asymmetry test (P = 0.56) indicated no potential publication bias. Conclusion Our meta-analytical evidence suggests that lncRNAs could be employed as a potential noninvasive diagnostic tool for OSCC.
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