| Yu Huang,Ping Peng,Peng Zhang,Lei Zhou,Yingying Wu. Analyses of the clinical characteristics of 49 cases of malignancy with multiple bone lesions as the first manifestation. Oncol Transl Med, 2021, 7: 83-87. |
| Analyses of the clinical characteristics of 49 cases of malignancy with multiple bone lesions as the first manifestation |
| Received:January 17, 2021 Revised:April 27, 2021 |
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| KeyWord:Bone lesions, malignancy, bone metastasis, clinical characteristics |
| Author Name | Affiliation | Postcode | | Yu Huang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 | | Ping Peng | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Peng Zhang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Lei Zhou | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yingying Wu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 |
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| Abstract: |
| Objective To investigate the clinical features of several cases of malignancy with multiple bone lesions
as the first manifestation.
Methods Forty-nine cases of malignancy with multiple bone lesions as the first manifestation were
retrospectively analyzed from May 2018 to July 2019. All patients complained of “pain at the site of bone
lesion” upon admission. Baseline patient information, such as age, gender, location of bone lesions,
etiology, diagnosis method, time of onset was collected.
Results The median age of the patients was 56 years old, of which 83.7% (41/49) were aged ≥50
years. The median time of onset was 2 months. Among the cases, 40 were confirmed as solid tumor bone
metastasis, whereas the remaining 9 cases as hematological system tumor. Lung cancer and multiple
myeloma were the main tumor types, accounting for 40.8% (20/49) and 16.3% (8/49), respectively. Other
common causes were seven cases of cancer affecting the digestive system (three cases of liver cancer,
three cases of gastric cancer, and one case of esophageal cancer), as well as seven cases of unknown
primary cancer. Half of the solid tumors had only multiple bone metastases but no other distant metastasis.
Conclusion Multiple bone lesions accompanied by pain may be the first clinical manifestation in various
malignant tumors. The common tumor types were lung cancer, multiple myeloma, and digestive system
tumor. It is more common in people aged 50 years and older. Multiple bone lesions might be the only
metastasis site of some solid tumors, and its mechanism needs further investigation |
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