| Guangcai Niu,Xiangdong Ma. The optional extent of lymph node dissection for pancreatic head cancer. Oncol Transl Med, 2021, 7: 20-24. |
| The optional extent of lymph node dissection for pancreatic head cancer |
| Received:May 10, 2020 Revised:January 20, 2021 |
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| KeyWord:pancreatic head cancer (PHC); standard regional lymphadenectomy (SRLN); extended regional lymphadenectomy (ERLN); survival; complication |
| Author Name | Affiliation | E-mail | | Guangcai Niu | Department of Oncological Surgery, Xuzhou Central Hospital | n10046@163.com | | Xiangdong Ma | Department of Oncological Surgery, Xuzhou Central Hospital | m10046@sina.com |
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| Abstract: |
| Objective The extent of lymph node dissection for pancreatic head cancer (PHC) is uncertain and
controversial; therefore, this study evaluated whether PHC patients can benefit from different extents of
lymph node dissection.
Methods A total of 106 PHC patients underwent standard regional lymphadenectomy (SRLN; n = 56,
52.8%) and extended regional lymphadenectomy (ERLN; n = 50, 47.2%) between September 2015 and
September 2019. None of the study participants had distant metastases. The median survival time and
complications were compared between the two groups.
Results The median survival time in the SRLN and ERLN groups was 27.01 months and 21.17 months,
respectively (P = 0.30). The postoperative major morbidity and mortality rates were 37.50% and 1.79% in the
SRLN group, and 46.00% and 2.00% in the ERLN group, respectively. Moreover, the tumor differentiation,
tumor diameter, lymph node involvement, perineural invasion, vascular invasion, and margin status all
correlated with survival (P < 0.05).
Conclusion For PHC patients, ERLN cannot provide a significant survival benefit over SRLN. Moreover,
ERLN increased morbidity and mortality, although without statistical significance. This indicates that ERLN
should not be considered in PHC patients. |
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