| Yang Tang,Li Yang,Wan Qin,Minxiao Yi,Bo Liu,Xianglin Yuan. A missense variant of MASP2 is associated with increased risk of radiation pneumonitis in lung cancer patients treated with radiation therapy. Oncol Transl Med, 2020, 6: 193-199. |
| A missense variant of MASP2 is associated with increased risk of radiation pneumonitis in lung cancer patients treated with radiation therapy |
| Received:May 07, 2020 Revised:September 01, 2020 |
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| KeyWord:radiation pneumonitis; lung cancer; mannan-binding lectin-associated serine protease 2 (MASP2); Single Nucleotide Polymorphisms (SNP) |
| Author Name | Affiliation | E-mail | | Yang Tang | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | tangyangtjmu@126.com | | Li Yang | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Wan Qin | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Minxiao Yi | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Bo Liu | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Xianglin Yuan | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | |
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| Abstract: |
| Objective In this study, mannan-binding lectin-associated serine protease 2 (MASP2) gene variant was
evaluated to assess the risk of radiation pneumonitis (RP) in patients with pulmonary malignancies.
Methods A total of 169 lung cancer patients with radiotherapy were included in our prospective study
(NCT02490319) and genotyped using the Sanger sequencing method. Multivariate Cox hazards analysis
and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of
all factors possibly associated with RP risk.
Results?Patients?with?mean?lung?disease?≥?15?Gy?and?V 20 ?≥?24%?had?higher?risk?of?RP?≥?grade?2
compared with their counterparts (HR = 1.888, 95% CI: 1.186–3.004, P = 0.007; HR = 2.126, 95% CI:
1.338–3.378, P = 0.001, respectively). Importantly, CC + CA genotype of MASP2: rs12711521 was strongly
associated?with?an?increased?occurrence?of?RP?≥?grade?2?(HR?=?1.949,?95%?CI:?1.278–2.971,?P = 0.002).
Conclusion MASP2: rs12711521?was?found?to?be?significantly?associated?with?RP?≥?grade?2?in?our?cohort
and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in
larger population. |
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