| Hui Peng,Zhimin Liu,Roshan Ara Ghoorun,Xianglin Yuan. Clinical characteristics and survival outcomes of perianal Paget’s disease: A SEER population-based study. Oncol Transl Med, 2020, 6: 1-9. |
| Clinical characteristics and survival outcomes of perianal Paget’s disease: A SEER population-based study |
| Received:January 07, 2020 Revised:March 11, 2020 |
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| KeyWord:perianal Paget’s disease (PPD); extramammary Paget’s disease; SEER database; survival analysis |
| Author Name | Affiliation | E-mail | | Hui Peng | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | denice1010@163.com | | Zhimin Liu | Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University (Gastrointestinal and Anal Hospital) | | | Roshan Ara Ghoorun | Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University (Gastrointestinal and Anal Hospital) | | | Xianglin Yuan | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | xlyuan1020@163.com |
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| Abstract: |
| Objective The aim of the study was to analyze the clinical features of patients with perianal Paget’s
disease (PPD) and investigate prognosis risk factors.
Methods The SEER*Stat software was used to identify 116 PPD patients from 1975 to 2015 in the
SEER research database. The Kaplan-Meier method was used to conduct a univariate analysis for PPD
patients. The differences in survival rates were evaluated using the log-rank test. The differences in the
clinicopathological features of PPD patients with or without anorectal carcinoma were compared using the
chi-square test.
Results The median survival time of PPD patients was 44 months. The median age of onset was 73
years old. The 43.10% of the patients were alive at the end of follow up, and only 12.93% of the patients
died of PPD. Elderly (age > 70 years; χ2 = 9.453, P = 0.002), poor differentiation (χ2 = 46.557, P = 0.000)
and abdominal perineal resection (APR; χ2 = 46.557, P = 0.000) were unfavorable risk factors of prognosis.
Nearly 50% of PPD had combined with other malignancies, and over 22.41% of those had multiple primary
neoplasms (3 or more). PPDs predisposed concurrent malignancy, and 48.21% of PPD patients with other
malignancies combined with anorectal carcinoma in the study. Stage (χ2 = 10.127, P = 0.018), and surgical
method (χ2 = 12.245, P = 0.007) were statistically significant in the PPD patients with or without anorectal
carcinoma. The 16.07% of patients had multiple lesions of Paget’s.
Conclusion Patients with PPD have a favorable survival, while the disease-specific mortality is low.
Diagnosed age, differentiation, and surgical methods were the influence factors of prognosis in PPD
patients. PPDs with anorectal carcinoma is of most important in further investigation. |
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