Shaojun Nong,Yangbo Guan,Zhongqing Wei#,Yueping Zhang,Bin Cheng,Chongsheng He,Limin Ma,Shujun Zhou,Wenguang Li,Jian Ni,Zhiwei Wang. Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population. Oncol Transl Med, 2019, 5: 278-284.
Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population
Received:December 11, 2019  Revised:January 04, 2020
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KeyWord:Interleukin-18; renal cell carcinoma; Polymorphism; Prognosis
Author NameAffiliationE-mail
Shaojun Nong Department of Urological Surgery,The Affiliated Hospital of Nantong University shaojunnong@sina.com 
Yangbo Guan Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Zhongqing Wei# Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Yueping Zhang Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Bin Cheng Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Chongsheng He Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Limin Ma Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Shujun Zhou Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Wenguang Li Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Jian Ni Department of Urological Surgery,The Affiliated Hospital of Nantong University  
Zhiwei Wang Department of Urological Surgery,The Affiliated Hospital of Nantong University  
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Abstract:
      Objective This study was to examine a possible association between two promoter polymorphisms, -137G/C and -607C/A, in the IL-18 gene and renal cell carcinoma occurrence and prognosis in Han Chinese. Methods We used a high-resolution melting method to genotype these two polymorphisms in 175 Chinese Han patients with renal cell carcinoma enrolled to follow-up in this study and in 200 age-matched healthy controls. Result Carriers of the GG genotype of the -137G/ C polymorphism had 2.165 time higher risk of renal cell carcinoma progression than carriers of GC[HR=2.15, 95%CI=1.270-3.687]. However, we found no significant association of genotype or allele distributions of these two polymorphisms with occurrence of renal cell carcinoma. Conclusion We conclude that there is evidence that the IL-18 gene promoter polymorphism -137G/C influences the prognosis of renal cell carcinoma patients.
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