| Guobo Du,Qian Zhou,Xinyao He,Long Cheng,Jing Zhou. Glioblastoma multiforme with metastasis to. Oncol Transl Med, 2020, 6: 36-38. |
| Glioblastoma multiforme with metastasis to |
| Received:November 26, 2019 Revised:March 12, 2020 |
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| KeyWord:extracranial glioblastoma; glioblastoma multiforme; metastases |
| Author Name | Affiliation | E-mail | | Guobo Du | Affiliated Hospital of North Sichuan Medical College | duguobo@yeah.net | | Qian Zhou | North Sichuan Medical College | | | Xinyao He | North Sichuan Medical College | | | Long Cheng | Affiliated Hospital of North Sichuan Medical College | | | Jing Zhou | Affiliated Hospital of North Sichuan Medical College | zj8126118@yeah.net |
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| Abstract: |
| Glioblastoma multiforme (GBM) is a common brain tumor that rarely metastasizes extra-cranially. We
present the case of a 40-year-old male with left temporal GBM who underwent craniotomy followed by
radiotherapy and chemotherapy. Postoperative MRI scans at different time intervals demonstrated a good
response. Eleven months after the initial diagnosis, there were no clinical or radiological signs suggesting
recurrence. However, the tumor showed metastasis simultaneously to the chest wall, lungs, and bone,
despite 2 cycles of chemotherapy. The patient developed paraplegia 14 months after the initial diagnosis
and died due to systemic failure 19 months after diagnosis. Extracranial metastasis of GBM is extremely
rare. We present the unusual case of a patient with GBM who showed simultaneous metastasis to the
lungs, bone, and chest wall. The prognosis of patients with extracranial metastasis of glioblastomas is very
poor, regardless of chemoradiotherapy. Newer approaches, such as immunotherapy and anti-angiogenic
therapy, need to be further studied. |
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