| Gang Zhou,Xiangyu Meng,Shangqin Liu. Association between diabetes mellitus, hypertension, hyperlipidemia, chronic viral hepatitis, and the risk of multiple myeloma: a case-control study. Oncol Transl Med, 2020, 6: 87-92. |
| Association between diabetes mellitus, hypertension, hyperlipidemia, chronic viral hepatitis, and the risk of multiple myeloma: a case-control study |
| Received:November 12, 2019 Revised:April 29, 2020 |
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| KeyWord:multiple myeloma (MM); diabetes mellitus (DM); hypertension; hyperlipidemia; chronic viral hepatitis; case-control study |
| Author Name | Affiliation | E-mail | | Gang Zhou | Department of Hematology, Zhongnan Hospital of Wuhan University | 1021848223@qq.com | | Xiangyu Meng | Department of Urology Surgery, Zhongnan Hospital of Wuhan University | | | Shangqin Liu | Department of Hematology, Zhongnan Hospital of Wuhan University | ubeliu@aliyun.com |
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| Abstract: |
| Objective This case-control study aimed to investigate whether diabetes mellitus (DM), hypertension,
hyperlipidemia, and chronic viral hepatitis are risk factors for multiple myeloma (MM). Moreover, the clinical
characteristics of MM patients with or without the abovementioned exposure factors were analyzed.
Methods In total, 340 MM patients and 680 patients with benign diseases who were hospitalized from
January 2012 to December 2017 were classified under the case group and control group, respectively.
Data about medical history of DM, hypertension, hyperlipidemia and chronic viral hepatitis were collected
by reviewing medical records. Univariate and multivariate analyses were conducted to compare the
history of DM, hypertension, hyperlipidemia, and viral hepatitis between the two groups. Considering DM,
hypertension, hyperlipidemia, and chronic viral hepatitis as exposure factors, clinical characteristics, such
as renal function and presence of fungal and other types of infections, between the exposed and nonexposed
groups were analyzed.
Results No significant difference was observed in the prevalence of DM, hypertension, and
hyperlipidemia between the case and control groups. MM patients had a higher prevalence of chronic viral
hepatitis than those with benign diseases. No significant difference was observed in the prevalence of renal
dysfunction, fungal infection, and non-fungal infections in MM patients with or without DM, hypertension,
and hyperlipidemia. MM patients with chronic viral hepatitis had a significantly higher prevalence of nonfungal
infections during hospitalization than those without.
Conclusion No significant association was noted between MM and DM, hypertension, and hyperlipidemia.
Chronic viral hepatitis is correlated to a significantly higher risk of MM, and MM patients with chronic viral
hepatitis were more susceptible to non-fungal infections during hospitalization. Although a non-significant
trend was observed in this study, we believe that DM and hypertension might be associated with a higher
risk of MM. Thus, large-scale studies must be conducted to validate the results of the current study |
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