Jinkun Guo,ZhongYin Zhou. Proton pump inhibitors and stomach neoplasm. Oncol Transl Med, 2020, 6: 26-29.
Proton pump inhibitors and stomach neoplasm
Received:October 15, 2019  Revised:December 30, 2019
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KeyWord:proton pump inhibitor (PPI); stomach neoplasm; review
Author NameAffiliationE-mail
Jinkun Guo Renmin hospital of wuhan university 2965570542@qq.com 
ZhongYin Zhou Renmin hospital of wuhan university gjk15107172941@163.com 
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      This study aimed to explore the relationship between proton pump inhibitors (PPIs) and gastric tumors and determine the reasons behind these connections. We reviewed studies on PPIs and stomach tumors. We explored the relationship between PPIs and different types of gastric neoplasms according to the classification of gastric neoplasms. Long-term use of PPIs is associated with stomach infection, high gastrin levels, and rebound acid hypersecretion, which are directly or indirectly related to the development of gastric neoplasms. PPIs can increase the risk of gastric fundal polyps. Further evidence is needed to prove that it can increase the risk of gastric cancer.