| Qian Zhang,Jie Tang,Xiaojie Ma,Jiayu Du. Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review. Oncol Transl Med, 2020, 6: 30-35. |
| Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review |
| Received:October 11, 2019 Revised:March 18, 2020 |
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| KeyWord:radiation-induced brain injury; nasopharyngeal carcinoma; VMAT |
| Author Name | Affiliation | E-mail | | Qian Zhang | Department of Oncology, affiliated Hospital of North Sichuan Medical College | 1002060536@qq.com | | Jie Tang | Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China | | | Xiaojie Ma | Department of Oncology, affiliated Hospital of North Sichuan Medical College | 992437730@qq.com | | Jiayu Du | Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China | |
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| Abstract: |
| A 61-year-old female nasopharyngeal carcinoma patient was admitted to the hospital with sudden
cognitive dysfunction one month after Volumetric Intensity Modulated Arc Therapy (VMAT) conventional
dose radiotherapy, and the initial diagnosis was radiation-induced brain injury (RBI). After comprehensive
treatment with steroid hormones, the patient’s condition rapidly improved. Typically, in nasopharyngeal
carcinoma patients treated with VMAT, the incidence of RBI is extremely low when the temporal lobe dose
is less than 65 Gy or 1% of the volume is less than 65 Gy. When this limit is exceeded, RBI may occur
in varying degrees. However, in this case, even though the temporal lobe dose was under the prescribed
limit, the patient still experienced RBI. The rare observations in this case can be used as a reference, and
clinicians should seriously consider the possibility of RBI in similar cases. |
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