Qian Zhang,Jie Tang,Xiaojie Ma,Jiayu Du. Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review. Oncol Transl Med, 2020, 6: 30-35.
Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review
Received:October 11, 2019  Revised:March 18, 2020
View Full Text  View/Add Comment  Download reader
KeyWord:radiation-induced brain injury; nasopharyngeal carcinoma; VMAT
Author NameAffiliationE-mail
Qian Zhang Department of Oncology, affiliated Hospital of North Sichuan Medical College 1002060536@qq.com 
Jie Tang Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
Xiaojie Ma Department of Oncology, affiliated Hospital of North Sichuan Medical College 992437730@qq.com 
Jiayu Du Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
Hits: 67
Download times: 162
Abstract:
      A 61-year-old female nasopharyngeal carcinoma patient was admitted to the hospital with sudden cognitive dysfunction one month after Volumetric Intensity Modulated Arc Therapy (VMAT) conventional dose radiotherapy, and the initial diagnosis was radiation-induced brain injury (RBI). After comprehensive treatment with steroid hormones, the patient’s condition rapidly improved. Typically, in nasopharyngeal carcinoma patients treated with VMAT, the incidence of RBI is extremely low when the temporal lobe dose is less than 65 Gy or 1% of the volume is less than 65 Gy. When this limit is exceeded, RBI may occur in varying degrees. However, in this case, even though the temporal lobe dose was under the prescribed limit, the patient still experienced RBI. The rare observations in this case can be used as a reference, and clinicians should seriously consider the possibility of RBI in similar cases.
Close