| Chao Zhang,Xiao Zou,Changyou Li,Gaoyang Lin,Yao Qi,Zhenfeng Li,Jing Xu,Tianhui Su,Xin Liu. Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy. Oncol Transl Med, 2019, 5: 211-217. |
| S100A7表达在预测乳腺癌保乳术联合放疗后复发的研究 |
| Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy |
| Received:August 13, 2019 Revised:November 23, 2019 |
| DOI：10.1007/s10330-019-0373-3 |
| 中文关键词: S100A7；保乳手术；放疗；复发；预后 |
| 英文关键词: S100A7; breast-conserving surgery; radiotherapy; locoregional recurrence; prognosis |
| 基金项目:吴阶平医学基金会(No. 320.6750.16229) |
| Author Name | Affiliation | E-mail | | Chao Zhang | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College | 18372704337@163.com | | Xiao Zou* | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College | 18372704337@163.com | | Changyou Li | Biotherapy Center, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Gaoyang Lin | Department of Thoracic Surgery, The Affiliated Qingdao Hiser Medical Center of Qingdao University, Qingdao | | | Yao Qi | Department of Pathology, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Zhenfeng Li | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Jing Xu | Department of Pathology, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Tianhui Su | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Xin Liu | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | |
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| 中文摘要: |
| [摘要] 材料与方法 S100A7在乳腺癌保乳联合放疗术后复发预测中的表达与预后的关系。选择349例癌组织蜡块从2011年1月到2014年1月在青岛中心医院,所有的病例采用手术,检测S100A7的肿瘤组织的表达,用单变量和多变量分析来评估S100A7蛋白质和临床结果之间的关系,探讨局部区域复发的独立危险因素(远程雷达)。结果 S100A7阳性表达率在复发组（66.7%）中高于未复发组（38.4%），P=0.025，差异具有统计学意义（P＜0.05）。Log-rank检验显示S100A7蛋白高表达与5年无局部区域复发生存率（RFS ）(94.9.% vs 89.5% P=0.0408)、无远处转移生存率（DFS）(95.4% vs 83.5% P＜0.001)、总生存率（OS）（99.0.% vs 92.5.5% P=0.0011)显著相关， P＜0.05。Cox多因素回归模型分析表明，S100A7的高表达是影响乳腺癌RFS的独立危险因素之一(HR=6.864, 95%CI: 1.575-29.915, P=0.01)。结论 S100A7过表达与与乳腺癌保乳术联合放疗局部复发和远处转移的风险增加有关，可作为筛选保乳术后放疗高复发风险患者的分子标志物。 |
| 英文摘要: |
| Objective To investigate the relationship between the expression of S100A7 protein and prediction of
recurrence and prognosis of breast cancer in patients undergoing breast-conserving surgery combined
with radiotherapy.
Methods 349 samples of carcinoma tissue wax blocks were selected from January 2011 to January
2014 in Qingdao Central Hospital. All the patients had undergone breast-conserving surgery. We analyzed
S100A7 expression in tumor tissue by immunohistochemical staining. Using univariate and multivariate
analyses, we evaluated the relationship between S100A7 and clinical results, to explore independent risk
factors for local regional recurrence (LRR).
Results The positive expression of S100A7 in the recurrence group (66.7%) was significantly higher
than in the non-recurrence group (38.4%), P = 0.025. A log-rank test showed that high S100A7 expression
was significantly correlated with 5-year regional recurrence free survival rate (RFS) (94.9% vs 89.5%, P =
0.0408), distant metastasis free survival rate (DFS) (95.4% vs 83.5%, P < 0.001), and overall survival rate
(OS) (99.0% vs 92.5%, P = 0.0011). Histological grade, vessel carcinoma embolus, lymph node metastasis,
S100A7 expression, and tumor size were factors that influenced RFS. Multivariate analysis of the Cox
proportional hazard model showed that high S100A7 expression was an independent risk factor that
affected breast cancer RFS (HR = 6.864, 95 % CI: 1.575 - 29.915, P = 0.01).
Conclusion We concluded that high S100A7 expression is associated with increased risk of LRR
and distant metastasis of breast cancer after breast-conserving surgery and postoperative radiotherapy.
S100A7 can be used as a molecular marker to screen for patients with high recurrence risk after breastconserving surgery |
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