| Chao Zhang,Xiao Zou,Changyou Li,Gaoyang Lin,Yao Qi,Zhenfeng Li,Jing Xu,Tianhui Su,Xin Liu. Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy. Oncol Transl Med, 2019, 5: 211-217. |
| Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy |
| Received:August 13, 2019 Revised:November 23, 2019 |
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| KeyWord:S100A7; breast-conserving surgery; radiotherapy; locoregional recurrence; prognosis |
| Author Name | Affiliation | E-mail | | Chao Zhang | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College | 18372704337@163.com | | Xiao Zou | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College | 18372704337@163.com | | Changyou Li | Biotherapy Center, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Gaoyang Lin | Department of Thoracic Surgery, The Affiliated Qingdao Hiser Medical Center of Qingdao University, Qingdao | | | Yao Qi | Department of Pathology, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Zhenfeng Li | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Jing Xu | Department of Pathology, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Tianhui Su | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Xin Liu | Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University, Qingdao 266003, China | |
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| Abstract: |
| Objective To investigate the relationship between the expression of S100A7 protein and prediction of
recurrence and prognosis of breast cancer in patients undergoing breast-conserving surgery combined
with radiotherapy.
Methods 349 samples of carcinoma tissue wax blocks were selected from January 2011 to January
2014 in Qingdao Central Hospital. All the patients had undergone breast-conserving surgery. We analyzed
S100A7 expression in tumor tissue by immunohistochemical staining. Using univariate and multivariate
analyses, we evaluated the relationship between S100A7 and clinical results, to explore independent risk
factors for local regional recurrence (LRR).
Results The positive expression of S100A7 in the recurrence group (66.7%) was significantly higher
than in the non-recurrence group (38.4%), P = 0.025. A log-rank test showed that high S100A7 expression
was significantly correlated with 5-year regional recurrence free survival rate (RFS) (94.9% vs 89.5%, P =
0.0408), distant metastasis free survival rate (DFS) (95.4% vs 83.5%, P < 0.001), and overall survival rate
(OS) (99.0% vs 92.5%, P = 0.0011). Histological grade, vessel carcinoma embolus, lymph node metastasis,
S100A7 expression, and tumor size were factors that influenced RFS. Multivariate analysis of the Cox
proportional hazard model showed that high S100A7 expression was an independent risk factor that
affected breast cancer RFS (HR = 6.864, 95 % CI: 1.575 - 29.915, P = 0.01).
Conclusion We concluded that high S100A7 expression is associated with increased risk of LRR
and distant metastasis of breast cancer after breast-conserving surgery and postoperative radiotherapy.
S100A7 can be used as a molecular marker to screen for patients with high recurrence risk after breastconserving surgery |
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