| Yindi Tian,Ya Guo,Yue Ke,Yuyan Guo,Pengtao Yang,Hongbing Ma,Baofeng Wang. Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis. Oncol Transl Med, 2019, 5: 223-228. |
| 维生素B12混合口服液治疗放射性食管炎的疗效观察 |
| Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis |
| Received:July 15, 2019 Revised:November 09, 2019 |
| DOI：10.1007/s10330-019-0367-7 |
| 中文关键词: 放射性黏膜炎；维生素B12；生活质量；KPS评分 |
| 英文关键词: esophagitis; vitamin B12; quality of life; Karnofsky performance status (KPS) |
| 基金项目:国家自然科学基金（No. 81872471）资助 |
| Author Name | Affiliation | Postcode | | Yindi Tian | Department of Infectious Diseases, The Second Affiliated Hospital of Medical College, Xi''an Jiaotong University, Xi''an 710004, China | 710004 | | Ya Guo | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Yue Ke | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Yuyan Guo | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Pengtao Yang | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Hongbing Ma | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Baofeng Wang* | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 |
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| 中文摘要: |
| 目的：研究维生素B12混合口服液治疗食管癌患者放射性食管炎的疗效。方法：采用随机对照研究，将75例符合入组条件的食管癌患者随机分为维生素B12混合口服液组（研究组：39例）和庆大霉素混合口服液组（对照组：36例），观察两组患者放射性食管炎分级、疼痛程度、体质量下降、KPS评分的变化。结果：对照组中１级放射性食管炎占总数的27.8％；２级放射性食管炎占41.7％；３、４级占对照组总数的30.6％；在Vitamin B12治疗组中１级放射性食管炎患者占总数的66.7％，２级占25.6％，３、４级占总数的7.7％，和对照组相比具有显著性差异（P<0.01）。同样，放射性食管炎引起的疼痛在Vitamin B12研究组也较对照组明显改善（P<0.05）。治疗结束后对照组平均体质量降低2.18±0.36，维生素B12治疗组平均体质量降低0.90±0.43（Ｐ＜０．０５）。治疗结束后Vitamin B12组较对照组患者ＫＰＳ评分提高，分别为86.2±1.2 和85.6±1.5，但无统计学差异（Ｐ＞０.０５）。结论：维生素B12混合口服液治疗能有效减少放射性食管炎的发生，减轻疼痛，改善患者的生活质量，提高治疗依从性。 |
| 英文摘要: |
| Objective This study aimed to investigate the effects of vitamin B12 mixed oral liquid in the treatment of
radiation-induced esophagitis in patients with esophageal cancer.
Methods Seventy-five patients with esophageal cancer who met the enrollment criteria were randomly
divided into the vitamin B12 mixed oral liquid group (39 patients in the study group) and the gentamicin
mixed oral liquid group (36 patients in the control group). The effects of the two treatment methods on
esophagitis grading, pain degree, body weight loss, and Karnofsky performance status (KPS) score in
patients with radiation esophagitis were observed.
Results In the control group, grade 1 radiation esophagitis accounted for 27.8% of the total patients,
grade 2 accounted for 41.7%, and grades 3 and 4 accounted for 30.6%. In the vitamin B12 treatment group,
grade 1 radiation esophagitis accounted for 66.7% of the total patients, grade 2 accounted for 25.6%, and
grades 3 and 4 accounted for 7.7%; there was a significant difference between the vitamin B12 treatment
group and control group (P < 0.01). Similarly, pain caused by radiation esophagitis was significantly
improved in the vitamin B12 group compared with the control group (P < 0.05). After treatment, the average
weight loss of the control group was (2.18 ± 0.36) kg, while that of the vitamin B12 treatment group was
(0.90 ± 0.43) kg (P < 0.05). The KPS scores of the vitamin B12 group were higher than those of the control
group, which were 86.2 ± 1.2 and 85.6 ± 1.5, respectively, but there was no statistical difference (P > 0.05).
Conclusion Vitamin B12 mixed oral liquid can effectively reduce the severity of radiation esophagitis,
relieve pain, improve patients’ quality of life, and increase treatment compliance. |
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