| Yindi Tian,Ya Guo,Yue Ke,Yuyan Guo,Pengtao Yang,Hongbing Ma,Baofeng Wang. Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis. Oncol Transl Med, 2019, 5: 223-228. |
| Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis |
| Received:July 15, 2019 Revised:November 09, 2019 |
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| KeyWord:esophagitis; vitamin B12; quality of life; Karnofsky performance status (KPS) |
| Author Name | Affiliation | Postcode | | Yindi Tian | Department of Infectious Diseases, The Second Affiliated Hospital of Medical College, Xi''an Jiaotong University, Xi''an 710004, China | 710004 | | Ya Guo | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Yue Ke | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Yuyan Guo | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Pengtao Yang | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Hongbing Ma | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 | | Baofeng Wang | Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China | 710004 |
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| Abstract: |
| Objective This study aimed to investigate the effects of vitamin B12 mixed oral liquid in the treatment of
radiation-induced esophagitis in patients with esophageal cancer.
Methods Seventy-five patients with esophageal cancer who met the enrollment criteria were randomly
divided into the vitamin B12 mixed oral liquid group (39 patients in the study group) and the gentamicin
mixed oral liquid group (36 patients in the control group). The effects of the two treatment methods on
esophagitis grading, pain degree, body weight loss, and Karnofsky performance status (KPS) score in
patients with radiation esophagitis were observed.
Results In the control group, grade 1 radiation esophagitis accounted for 27.8% of the total patients,
grade 2 accounted for 41.7%, and grades 3 and 4 accounted for 30.6%. In the vitamin B12 treatment group,
grade 1 radiation esophagitis accounted for 66.7% of the total patients, grade 2 accounted for 25.6%, and
grades 3 and 4 accounted for 7.7%; there was a significant difference between the vitamin B12 treatment
group and control group (P < 0.01). Similarly, pain caused by radiation esophagitis was significantly
improved in the vitamin B12 group compared with the control group (P < 0.05). After treatment, the average
weight loss of the control group was (2.18 ± 0.36) kg, while that of the vitamin B12 treatment group was
(0.90 ± 0.43) kg (P < 0.05). The KPS scores of the vitamin B12 group were higher than those of the control
group, which were 86.2 ± 1.2 and 85.6 ± 1.5, respectively, but there was no statistical difference (P > 0.05).
Conclusion Vitamin B12 mixed oral liquid can effectively reduce the severity of radiation esophagitis,
relieve pain, improve patients’ quality of life, and increase treatment compliance. |
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