Xiaoying Quan. The combined prognostic value of pretreatment neutrophil-to-lymphocyte ratio, lymphocyte-tomonocyte ratio, and platelet-to-lymphocyte ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2019, : 137-146.
The combined prognostic value of pretreatment neutrophil-to-lymphocyte ratio, lymphocyte-tomonocyte ratio, and platelet-to-lymphocyte ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma
Received:May 06, 2019  Revised:July 23, 2019
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KeyWord:extranodal natural killer/T-cell; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; platelet-to-lymphocyte ratio; prognosis
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Xiaoying Quan Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu 1193084163@qq.com 
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Abstract:
      Objective This study aimed to explore the combined prognostic value of pretreatment neutrophil-tolymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in newly diagnosed IE/IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with a P-Gemox regimen combined with radiotherapy or radiotherapy alone. Methods A total of 132 patients from 2009 to 2017 at the Sichuan Cancer Hospital were enrolled in the study. The cutoff values of NLR, LMR, and PLR using overall survival (OS) rate as an endpoint were obtained by the receiver operating curve. Results The cutoff value of NLR was 3.5. Patients with high NLR had significantly shorter progressionfree survival (PFS) (P < 0.001) and OS (P < 0.001) than those with low NLR. Similarly, the cutoff value of LMR was 3.0. The high LMR group had significantly longer PFS (P=0.001) and OS (P < 0.001) than the low LMR group. Similarly, the cutoff value of PLR was 191.7. The high PLR group was significantly associated with poor PFS (P < 0.001) and OS (P < 0.001) than the low PLR group. Furthermore, combining NLR, LMR, and PLR to build a new model to stratify patients into low-, intermediate-, intermediate-high-, and high-risk groups, there were also significant differences in PFS (P < 0.001) and OS (P < 0.001). The univariate analysis showed that presenting B symptoms, stage IIE, local tumor invasion, Eastern Cooperative Oncology Group score ≥ 2, elevated lactate dehydrogenase level, elevated NLR, decreased LMR, and elevated PLR were significantly associated with poor survival. The multivariate analysis demonstrated that PLR was an independent prognostic factor for both PFS (hazard ratio [HR] = 2.073, 95% confidence interval [CI] = 1.080–3.981, P = 0.028) and OS (HR = 2.127, 95% CI = 1.102–4.107, P = 0.025). Conclusion Elevated pretreatment PLR was a novel simple predictor of poor survival in patients with stage IE/IIE ENKTL. Combining NLR, LMR, and PLR could provide additional stratification.
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