Luo Zhigang. Regulatory mechanisms of long non-coding RNAs. Oncol Transl Med, 2019, 5: 147-151.
Regulatory mechanisms of long non-coding RNAs
Received:March 28, 2019  Revised:March 28, 2019
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KeyWord:long non-coding RNAs (lncRNAs); regulatory mechanisms; transcriptional factors; chromatin state, alternative splicing; RNA editing, microRNA (miRNA)
Author NameAffiliationAddress
Luo Zhigang People’s Hospital of Jianyang city,Jianyang city Sichuan 644000 四川省简阳市医院路180号
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      Long non-coding RNAs (lncRNAs) belong to a large and complex family of RNAs, which play many important roles in regulating gene expression. However, the mechanism underlying the dynamic expression of lncRNAs is still not very clear. In order to identify lncRNAs and clarify the mechanisms involved, we collected basic information and highlighted the mechanisms underlying lncRNA expression and regulation. Overall, lncRNAs are regulated by several similar transcription factors and protein-coding genes. Epigenetic modification (DNA methylation and histone modification) can also downregulate lncRNA levels in tissues and cells. Moreover, lncRNAs may be degraded or cleaved via interaction with miRNAs and miRNAassociated protein complexes. Furthermore, alternative RNA splicing (AS) may play a significant role in the post-transcriptional regulation of lncRNAs.