Xiaoying Quan,Chunzhi Wu,Lei Lei,Xiaoyan Chen,Bin Ye. The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2019, 5: 162-169.
The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma
Received:March 26, 2019  Revised:September 09, 2019
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KeyWord:?Key words: C-reactive protein to albumin ratio (CRP/Alb); extranodal NK/T cell lymphoma; prognosis ?introduction
Author NameAffiliationE-mail
Xiaoying Quan Department of Medical Oncology, The Sixth People''s Hospital of Chengdu 1193084163@qq.com 
Chunzhi Wu The Sixth People''s Hospital of Chengdu  
Lei Lei Department of Medical Oncology, The Sixth People''s Hospital of Chengdu  
Xiaoyan Chen Department of Medical Oncology, The Sixth People''s Hospital of Chengdu  
Bin Ye Department of Medical Oncology, The Sixth People''s Hospital of Chengdu 354539616@qq.com 
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Abstract:
      ?Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-to- albumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients. Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients. Methods One hundred and fourteen patients diagnosed with extranodal NK/T cell lymphoma at Sichuan Cancer Hospital from September 2011 to November 2016 were retrospectively reviewed. An optimal cutoff value of CRP/Alb for overall survival rate as an endpoint was obtained using the receiver operating curve (ROC). Results The optimal cutoff value of CRP/Alb was 0.15. For the low CRP/Alb group, the 3-year progression-free survival (PFS) was 78.6% and the 3-year overall survival (OS) was 80.7%. The 3-year PFS and OS values for the high CRP/Alb group were 41.6% and 45.2%, respectively. Differences for PFS (P < 0.001) and OS (P < 0.001) between the two groups were statistically significant. Univariate analysis showed that ECOG, IPI, CRP, GPS, and CRP/Alb were significantly associated with PFS. Similarly, all five were also significantly associated with OS. Multivariate analysis further confirmed that ECOG and CRP/ Alb were independent prognostic factors for both PFS and OS. Moreover, the cutoff value of CRP/Alb showed superior prognostic ability in discriminating between patients with different outcomes in low-risk group based on GPS, IPI, and KPI scores. Conclusion CRP/Alb is a promising prognostic marker for early-stage extranodal NK/T cell lymphoma.
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