| Yiliyaer,Yusufu Maimaiti. Aurora kinases: novel anti-breast cancer targets. Oncol Transl Med, 2019, 5: 43-48. |
| Aurora kinases: novel anti-breast cancer targets |
| Received:November 07, 2018 Revised:March 02, 2019 |
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| KeyWord:aurora kinases; breast cancer; inhibitors |
| Author Name | Affiliation | E-mail | | Yiliyaer | xinjiang medical university | 2476787631@qq.com | | Yusufu Maimaiti | People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, China | |
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| Abstract: |
| Aurora kinases regulate multiple steps of mitotic cell division in eukaryotic cells. Overexpression of aurora
kinases has been observed in some tumor cells, which suggests that abnormalities in aurora kinases
are closely related to tumorigenesis. In additon, aurora kinases are often amplified or overexpressed in
breast cancer cells, leading to chromosomal segregation abnormalities and genomic disorder, and thereby
activating oncogenic pathways. Novel Aurora A kinase inhibitors are currently being studied in multiple phase
I and II studies. In this review, we describe the biological functions and mechanisms of aurora kinases in
breast cancer cells and summarize the preclinical findings related to aurora kinases in breast cancer. |
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