| Lingjun Meng,Fangzhen Shen. Expression and clinical significance of serum lipoprotein (a) in patients with gastric cancer. Oncol Transl Med, 2018, 4: 242-246. |
| Expression and clinical significance of serum lipoprotein (a) in patients with gastric cancer |
| Received:October 12, 2018 Revised:January 08, 2019 |
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| KeyWord:lipoprotein (a) [LP (a)]; gastric cancer; staging; differentiation; pathological typing |
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| Abstract: |
| Objective: This study aimed to investigate the expression and clinical significance of serum lipoprotein (a)
[LP (a)] in patients with gastric cancer.
Methods: Two hundred and twenty-two patients with gastric cancer (gastric cancer group) were selected
from 2015 to 2017 [mean age (58.40 ± 10.40) years], as were 101 healthy persons [normal age group, mean
age (58.18 ± 11.42) years]. Fasting blood samples were collected and evaluated by immunoturbidimetry
with a biochemical analyzer. LP (a) concentration was observed and its difference was compared.
Results: There was no significant correlation between LP (a) and tumor stage (P > 0.05). Compared with
the control group, the level of LP (a) in the male gastric cancer group was significantly higher than that in
the control group (P < 0.05). In the subgroup analysis, the level of LP (a) and abnormal rate showed an
increasing trend among patients with stages I–IV gastric cancer. The level of LP (a) in poorly differentiated
gastric cancer patients was higher than that in the high middle differentiation group (P < 0.05). There was
no significant difference in LP (a) levels among patients with different pathological types of gastric cancer
(P > 0.05).
Conclusion: LP (a) was correlated with the occurrence, development and differentiation of gastric cancer,
but not with the pathological classification of gastric cancer. Serum LP (a) concentration may be used as
an indicator for the staging and prognosis of gastric cancer, but the specific underlying mechanism remains
to be further studied. |
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