Yunsheng Wang,Qinjiang Liu,Youxin Tian. Correlation between sodium-iodide symporter expression and circulating tumor cell positivity in differentiated thyroid carcinoma. Oncol Transl Med, 2018, 4: 68-71.
Correlation between sodium-iodide symporter expression and circulating tumor cell positivity in differentiated thyroid carcinoma
Received:March 18, 2018  Revised:May 19, 2018
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KeyWord:differentiated thyroid cancer (DTC); sodium-iodide symporter (NIS); circulating tumor cell flow cytometry
Author NameAffiliationE-mail
Yunsheng Wang Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province wangys208@foxmail.com 
Qinjiang Liu Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province LIUQJ99@126.com 
Youxin Tian Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province  
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Abstract:
      Objective?We investigated the correlation between the expression of the sodium-iodide symporter (NIS) and the detection of circulating tumor cells (CTCs) in differentiated thyroid carcinoma (DTC). Methods?NIS expression in differentiated thyroid and the positive rate of CTCs in the peripheral blood were determined by immunohistochemistry S-P and flow cytometry from the records of 172 cases of differentiated thyroid carcinoma. Results?Seventy-six cases (44.2%) expressed NIS in the differentiated thyroid and 63 cases (36.6%) were positive for CTCs in the peripheral blood. There was a significant difference between N0 and N1 in the expression of NIS (χ2 = 6.015, P = 0.014) and the positive rate of CTCs (χ2 = 14.035, P = 0.001). N0 and N1 also differed significantly in the expression of NIS (r = -0.383, -0.610, P = 0.002, < 0.001). The differences in the NIS expression, but not in the positive rate of CTCs, were significant among the different pathological subtypes (χ2 = 7.897, P = 0.005; χ2 = 1.455, P = 0.228, respectively). There was a significant negative correlation between the highly differentiated type and intermediate differentiation type both in the expression of NIS and positive rate of CTCs (r = -0.591, -0.443, P < 0.001, P = 0.002). Conclusion?There was a significant negative correlation between the expression of tissue NIS and positive rate of CTCs in the peripheral blood in DTC. The malignancy level and lymph node metastasis in differentiated thyroid carcinoma were negatively correlated with NIS expression and positively correlated with the positive rate of CTC.
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