| wei chen. Expression and clinical significance of MCM5 and P16 in hyperplastic disease of the cervix. Oncol Transl Med, 2018, 4: 13-17. |
| 宫颈增生性疾病中MCM5和P16的表达及意义 |
| Expression and clinical significance of MCM5 and P16 in hyperplastic disease of the cervix |
| Received:March 01, 2018 Revised:March 28, 2018 |
| DOI：10.1007/s10330-018-0257-7 |
| 中文关键词: MCM5；P16；, 宫颈癌；免疫组织化学 |
| 英文关键词: cervical cancer; P16; MCM5; immunohistochemistry |
| 基金项目: |
| Author Name | Affiliation | E-mail | | wei chen* | the Sixth People Hospital of Chongqing, | trade468@126.com |
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| 中文摘要: |
| 【目的】探讨MCM5和P16在宫颈增生性病变（宫颈上皮内瘤变及宫颈癌）组织中的表达及临床病理意义。【方法】采用免疫组化技术(SP法)检测MCM5和P16在30例正常宫颈组织和100例宫颈CIN和宫颈癌中的表达。【结果】 MCM5和P16在正常宫颈黏膜上皮、 CINI、CINII级、CINⅢ级、浸润癌表达的阳性率分别为6.7%、35.0%、40.0%、70.0%、97.5 %和6.7%、30.0%、45.0%、75.0%、100%。正常组织与CIN及宫颈癌相比MCM5及P16的表达率差异具有显著性 (p<0.05)；在宫颈癌中 MCM5的表达与P16表达呈正相关关系(p<0.01))，MCM5和P16表达率与临床分期及病理分级有关(p<0.05) 。【结论】 MCM5和P16可作为反映宫颈上皮增生病变程度的常用指标，两者联合检查对宫颈上皮内瘤变（CIN）及宫颈癌的诊断及鉴别有一定参考价值。 |
| 英文摘要: |
| Objective The aim of the study was to study the expression and clinical significance of MCM5 and P16
in cervical intraepithelial neoplasia (CIN) and cervical cancer.
Methods The immunohistochemistry S-P method was used to detect the expression of MCM5 and P16
in 100 cases of cervical CIN and cancer.
Results The positive expression rates of MCM5 and P16 in normal cervical epithelium, CIN I, CIN II, CIN
III, and cervical invasive cancer were 6.7%, 35.0%, 40.0%, 70.0%, and 97.5%, and 6.7%, 30.0%, 45.0%,
75.0%, and 100%, respectively. The positive expression rates of MCM5 and P16 significantly differed
between CIN and infiltrating carcinoma (P < 0.05). The expression levels of MCM5 and P16 positively
correlated in cervical cancer (P < 0.01). The positive expression of MCM5 and P16 closely correlated with
the clinical stage and pathological grade of cervical cancer (P < 0.05).
Conclusion MCM5 and P16 might be used as markers for aggressive biological behavior in cervical
cancer and might be useful for distinguishing CIN and cervical cancer. |
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