| wei chen. Expression and clinical significance of MCM5 and P16 in hyperplastic disease of the cervix. Oncol Transl Med, 2018, 4: 13-17. |
| Expression and clinical significance of MCM5 and P16 in hyperplastic disease of the cervix |
| Received:March 01, 2018 Revised:March 28, 2018 |
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| KeyWord:cervical cancer; P16; MCM5; immunohistochemistry |
| Author Name | Affiliation | E-mail | | wei chen | the Sixth People Hospital of Chongqing, | trade468@126.com |
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| Abstract: |
| Objective The aim of the study was to study the expression and clinical significance of MCM5 and P16
in cervical intraepithelial neoplasia (CIN) and cervical cancer.
Methods The immunohistochemistry S-P method was used to detect the expression of MCM5 and P16
in 100 cases of cervical CIN and cancer.
Results The positive expression rates of MCM5 and P16 in normal cervical epithelium, CIN I, CIN II, CIN
III, and cervical invasive cancer were 6.7%, 35.0%, 40.0%, 70.0%, and 97.5%, and 6.7%, 30.0%, 45.0%,
75.0%, and 100%, respectively. The positive expression rates of MCM5 and P16 significantly differed
between CIN and infiltrating carcinoma (P < 0.05). The expression levels of MCM5 and P16 positively
correlated in cervical cancer (P < 0.01). The positive expression of MCM5 and P16 closely correlated with
the clinical stage and pathological grade of cervical cancer (P < 0.05).
Conclusion MCM5 and P16 might be used as markers for aggressive biological behavior in cervical
cancer and might be useful for distinguishing CIN and cervical cancer. |
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