Fei Gao,Lin Jia,Jianjun Han,Jisheng Wang,Yun Wang. Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer. Oncol Transl Med, 2018, 4: 1-5.
Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer
Received:February 07, 2018  Revised:March 29, 2018
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KeyWord:transforming growth factor-β; esophagus cancer; radiotherapy; short-term efficacy; prediction
Author NameAffiliationE-mail
Fei Gao The Oncology Department of The Third Hospital of Mianyang,Sichuan,China 6221252@qq.com 
Lin Jia The Oncology Department of The Third Hospital of Mianyang,Sichuan,China  
Jianjun Han The Oncology Department of The Third Hospital of Mianyang,Sichuan,China  
Jisheng Wang Pharmacy department of The Third Hospital of Mianyang,Sichuan,China  
Yun Wang The Oncology Department of The Third Hospital of Mianyang,Sichuan,China  
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Abstract:
      Objective To investigate variation in levels of transforming growth factor beta 1 (TGF-β1) before and after radiotherapy in patients with esophageal cancer in order to evaluate the predictive value of TGF-β1 for the effects of radiotherapy Methods A total of 140 patients with esophageal squamous carcinoma undergoing radical radiation therapy in the Department of Oncology from March 2015 to December 2017 were enrolled. The patients were divided into the effective (115 cases) and ineffective (25 cases) groups according to World Health Organization (WHO) criteria for the evaluation of solid tumors (2009 RECIST standard). TGF-β1 levels were measured in all patients by using enzyme-linked immunosorbent assay (ELISA). Multiple-factor analysis of the predictive value of the treatment efficacy was performed by Cox regression analysis. Results After radiotherapy, 36, 79, and 25 cases experienced complete response (CR), partial response(PR), and no response (NR), respectively, with a total effective rate of 82.14%. The TGF-β1 level was significantly lower in the effective group than that in the ineffective group (P < 0.05) and covariance analysis revealed significantly reduced TGF-β1 level in esophageal cancer patients following radiotherapy. The multi-factor Cox regression model revealed that the predictive value of TGF-β1 for the effect of radiotherapy was largest, with a hazard ratio [HR] of 1.955 (P = 0.002), followed by exposure dose, with (HR = 1.367; P = 0.035). Conclusion Serum TGF-β1 level can serve as a predictor for the short-term effects of radiotherapy in patients with esophageal cancer.
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